服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. The D816V substitution in the cKIT kinase domain has been identified in peripheral blood mononuclear cells of patients suffering from mastocytosis with an associated hematologic disorder. Gastrointestinal stromal tumors (GIST), acute myeloid leukemia, and germ cell tumors have also been demonstrated to carry this mutation. 产品介绍 The cKIT (D816V) Assay Kit is designed to measure cKIT (D816V) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 PIM kinases (PIM1, PIM2 and PIM3) are a family of serine/threonine protein kinases that play crucial roles in cell survival, proliferation, and drug resistance. PIM kinases are overexpressed in several tumors and promote growth and survival of malignant cells through cell cycle regulation and/or inhibition of apoptosis. Recently, PIM kinases were identified as a potential therapeutic target for precision medicine of advanced cancer. 产品介绍 The PIM3 Assay Kit is designed to measure PIM3 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 PIM kinases (PIM1, PIM2 and PIM3) are a family of serine/threonine protein kinases that play crucial roles in cell survival, proliferation, and drug resistance. PIM kinases are overexpressed in several tumors and promote growth and survival of malignant cells through cell cycle regulation and/or inhibition of apoptosis. Recently, PIM kinases were identified as a potential therapeutic target for precision medicine of advanced cancer. 产品介绍 The PIM1 Assay Kit is designed to measure PIM1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 PIM kinases (PIM1, PIM2 and PIM3) are a family of serine/threonine protein kinases that play crucial roles in cell survival, proliferation, and drug resistance. PIM kinases are overexpressed in several tumors and promote growth and survival of malignant cells through cell cycle regulation and/or inhibition of apoptosis. Recently, PIM kinases were identified as a potential therapeutic target for precision medicine of advanced cancer. 产品介绍 The PIM2 Assay Kit is designed to measure PIM2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 The Cereblon Ubiquitination Homogeneous Assay Kit is designed to measure Cereblon auto-ubiquitination activity in a homogeneous 384 reaction format. It utilizes biotin-labeled ubiquitin and proper A-screen beads to complete the pairing. This homogeneous assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications.
询价背景介绍 TBK1 (TANK-binding kinase 1) is a ubiquitously expressed serine/threonine kinase that belongs to the non-canonical IκB kinase (IKKs) family. TBK1 plays a critical role in controlling Type I interferon production through the IRF3 signaling pathway, suggesting it could be a promising drug target for autoimmune diseases such as interferonopathies. 产品介绍 The TBK1 Assay Kit is designed to measure TBK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 Cell signaling through the PD-1 receptor upon binding the PD-L1 ligand attenuates immune responses and this pathway is exploited by both tumors and viruses. The Monkey PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling pathway in the animal model cynomolgus monkey (Macaca fascicularis). The key to this kit is the high sensitivity of detection of biotin-labeled PD-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, PD-L1 is coated on a 96-well plate. Next, PD-1 is incubated with PD-L1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
询价产品介绍 Ready to use Kinase substrate (50X) STAT5 peptide is a peptide derived from the sequence motif of the STAT5.
询价产品介绍 Cell signaling through the PD-1 receptor upon binding the PD-L1 ligand attenuates immune responses and this pathway is exploited by both tumors and viruses. The Monkey PD-1:PD-L1[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this signaling pathway in the animal model cynomolgus monkey (Macaca fascicularis).
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