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产品介绍 The FGFR3 (V443M) Assay Kit is designed to measure FGFR3 (V443M) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 c-KIT is a proto-oncogene and a type III transmembrane receptor for mast cell growth factor, also known as stem cell factor. It plays an essential role in the regulation of cell survival and proliferation, as well as hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and mast cell development, migration and function. Activating mutations in cKIT are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, melanoma, and acute myeloid leukemia, while inactivating mutations are associated with the genetic defect piebaldism. 产品介绍 The cKIT Assay Kit is designed to measure cKIT activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价产品介绍 Aqueous buffer containing biotinylated substrate optimized for use with BPS Bioscience’s poly(ADP) ribose polymerase (PARP) assay kits: Optimized for use with:PARP6 Chemiluminescent Assay Kit (BPS Bioscience #80556), PARP7 Chemiluminescent Assay Kit (BPS Bioscience #79729), PARP7 (TIPARP) Chemiluminescent Assay Kit (BPS Bioscience #80557), PARP11 Chemiluminescent Assay Kit (BPS Bioscience #80561), PARP14 Chemiluminescent Assay Kit (BPS Bioscience #80568)
询价背景介绍 MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a cysteine protease that structurally resembles caspases. MALT1 is a member of the CARMA1-BCL10-MALT1 (CBM) complex that mediates NF-κB activation downstream of the B cell receptor, T cell receptor and ITAM-coupled natural killer cell receptors. MALT1 cleavage activity is essential to T cell and B cell activation and is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. 产品介绍 The Fluorogenic MALT1 Assay Kit is designed to measure MALT1 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 Lymphotoxin β receptor (LTβR) and herpes virus entry mediator (HVEM) are the physiological receptors of LIGHT (tumor necrosis factor superfamily member 14 (TNFSF14) or CD258). The activation of the LTβR/HVEM:LIGHT co-signaling pathways induces the production of pro-inflammatory molecules, like NF-κB, chemokines and adhesion molecules. LTβR is up regulated in hepatitis and hepatocellular carcinoma, and influences lipid metabolism and atherosclerosis. It also regulates cell growth and can initiate inflammation related carcinogenesis. 产品介绍 The LTβR:LIGHT[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of LIGHT binding to LTβR . This kit comes in a convenient 96-well format, with biotin-labeled LIGHT, purified LTβR , streptavidin-labeled HRP, and assay buffer for 100 binding reactions. The key to this kit is the high sensitivity of detection of biotin-labeled LIGHT by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, LTβR is coated on a 96-well plate. Next, biotinylated LIGHT is incubated with LTβR on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
询价背景介绍 FGFR4 (Fibroblast Growth Factor Receptor 4) is a member of a family of tyrosine kinases involved in many pathways that play a significant role in cancer. FGFR4 is highly expressed in embryonic tissues and is involved in embryonic development, angiogenesis, and tissue differentiation. In adults, it is involved in bile regulation, metabolism, and tissue repair. Overexpression of FGFR4 has been detected in multiple types of human cancer, such as breast, liver, colon, and prostate cancers, and is associated with resistance to chemotherapy and radiation. Therefore FGFR4 is of great interest as a target for cancer therapies. 产品介绍 The FGFR4 Assay Kit is designed to measure FGFR4 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 FGFR2 (Fibroblast Growth Factor Receptor 2) is a member of a family of tyrosine kinases involved in many pathways that play a significant role in cancer. Amplification or activation of FGFR2 has been reported in breast and gastric cancers, while FGFR2 mutations have been observed in endometrial and breast cancers. Mutations in FGFR2 are also associated with bone development disorders including Pfeiffer Syndrome and Crouzon Syndrome. 产品介绍 The FGFR2 Assay Kit is designed to measure FGFR2 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 The FLT3 Kinase Assay Kit is designed to measure FLT3 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价背景介绍 LCK is a tyrosine kinase that phosphorylates the CD3 receptor and is essential for T cell development and activation. LCK also associates with the cytoplasmic domains of the CD4 and CD8 glycoproteins and interacts with the beta-chain of the interleukin-2 receptor. LCK inhibitors are being investigated as a promising therapeutic approach to autoimmune disease and other inflammatory disorders. 产品介绍 The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
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