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产品介绍 This 2X KRAS Nucleotide Exchange Buffer is optimized for use with the KRAS Nucleotide Exchange Assay Kits.
询价背景介绍 It is well established that RAS mutations are responsible more than 30% of human cancers and KRAS(G12C) is one of the KRAS mutations that is found frequently in lung and colon cancers. Recent studies discovered a small molecule called AMG510 (Amgen) that can block the KRAS(G12C)-mediated signaling pathway by locking the KRAS conformation in the GDP-bound state. Compounds that affect the nucleotide exchange (GDP to GTP) reaction in KRAS could lead to a novel approach to the inhibition of tumor cell growth in KRAS(G12C)-driven tumors. 产品介绍 The KRAS(G12C) Nucleotide Exchange Assay Kit is designed for screening and profiling of KRAS(G12C) antagonists/inhibitors by using BODIPY-GDP to monitor the GDP or GTP binding status. The kit can be used with two different protocols for greater flexibility, either titrating the inhibitor with fixed GTP concentration or titrating the GTP with fixed inhibitor concentration.
询价产品介绍 The JMJD1B Homogeneous Assay Kit is designed to measure JMJD1B activity for screening and profiling applications. JMJD1B, also known as JHDM2B and KDM3B, is a JumonjiC (JmjC) domain containing histone lysine demethylase that exhibits demethylation activity toward H3-K9Me3 and H3-K36Me3. TThe key to the JMJD1B Homogeneous Assay Kit is a highly specific antibody that recognizes demethylated substrate. With this kit, only three simple steps on a microtiter plate are required for methyltransferase detection. First, a sample containing JMJD1B enzyme is incubated with the biotinylated substrate. Next, acceptor beads and primary antibody are added, then donor beads, followed by reading the Alpha-counts. Our histone demethylase assays utilize highly specific antibodies that recognize demethylated products. First, a sample containing the enzyme is incubated with a biotinylated substrate. Next, acceptor beads and primary antibody are added, then donor beads, followed by reading the Alpha-counts, as shown above.
询价产品介绍 The JMJD2D Homogeneous Assay Kit is designed to measure JMJD2D activity for screening and profiling applications. JMJD2D, also known as KDM4D, is a JumonjiC (JmjC) domain containing histone lysine demethylase that exhibits demethylation activity toward H3-K9Me3 and H3-K36Me3. The key to the JMJD2D Homogeneous Assay Kit is a highly specific antibody that recognizes demethylated substrate. With this kit, only three simple steps on a microtiter plate are required for methyltransferase detection. First, a sample containing JMJD2D enzyme is incubated with the biotinylated substrate. Next, acceptor beads and primary antibody are added, then donor beads, followed by reading the Alpha-counts. Our histone demethylase assays utilize highly specific antibodies that recognize demethylated products. First, a sample containing the enzyme is incubated with a biotinylated substrate. Next, acceptor beads and primary antibody are added, then donor beads, followed by reading the Alpha-counts, as shown above.
询价背景介绍 SHP1 (also known as PTPN6) is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine-stimulated cells. The noncatalytic N-terminus of this phosphatase can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 is involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to function through dephosphorylating molecules related to the MAP kinase pathway. 产品介绍 The Fluorogenic SHP1 Assay Kit is designed to measure SHP1 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps. This kit is developed to identify inhibitors of the regulatory region of SHP1.
询价产品介绍 Platelet-derived growth factor receptor A or PDGFRα has been implicated in regulation of cell growth and survival, apoptosis, and differentiation. It has been identified as a potential target in eosinophilic leukemia cancer, inflammatory breast cancer, and gastrointestinal stromal tumors. The D842V is one of the most predominant of the D842 mutations, which are related to gastrointestinal stromal tumors and are associated with resistance to tyrosine kinase inhibitors. The PDGFRα (D842V) Assay Kit is designed to measure PDGFRα (D842V) activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价背景介绍 B7-1, also known as CD80, is a membrane receptor found in activated antigen presenting cells (APC). In addition to PD-1, PD-L1 is able to bind to B7-1, resulting in inhibition of T cell activation and cytokine production. This immune checkpoint is another target of interest for immunoregulatory functions in oncology and other disease areas. Mouse PD-L1 and B7-1 are the respective orthologs of the human proteins, so they can be used for research in animal models. 产品介绍 The PD-L1:B7-1 [Biotinylated] Inhibitor Screening Assay Kit (Mouse) is designed for screening and profiling inhibitors of murine PD-L1 binding to murine B7-1. The key to this kit is the high sensitivity of detection of biotin-labeled B7-1 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, PD-L1 is coated on a 96-well plate. Next, biotinylated B7-1 is incubated with PD-L1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
询价产品介绍 The FGFR3 (V443L) Assay Kit is designed to measure FGFR3 (V443L) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 The FGFR3 (L496V) Assay Kit is designed to measure FGFR3 (L496V) activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
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