服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 c-Met, also known as HGFR (hepatocyte growth factor receptor), is a receptor protein tyrosine kinase encoded by the gene MET. Upon binding its ligand HGF (hepatocyte growth factor), c-Met activates multiple cellular processes including proliferation, adhesion and angiogenesis. Importantly, many studies report that c-Met is overexpressed in various carcinomas, suggesting that targeting HGF/c-Met signaling could be a promising target for cancer treatment. A splice mutation that results in skipping exon 14 has been identified in ~4% of lung cancer patients, particularly those with non small cell lung cancer. This mutation causes over-expression of MET protein and increased MET activation, leading to oncogenesis. 产品介绍 The c-Met (del 963-1009) Kinase Assay Kit is designed to measure the kinase activity of c-Met (del 963-1009, exon 14 deletion) for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The recombinant protein used in the kit corresponds to amino acids 956-1390 of c-Met that contain the tyrosine kinase domain. The recombinant protein also contains a deletion of amino acids 963-1009 corresponding to exon 14 skipping.
询价背景介绍 MMP8 (matrix metalloproteinase 8) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP8 is also associated with the regulation of cytokines and chemokines, suggesting a role for MMP8 in inflammation. 产品介绍 The Fluorogenic MMP8 Assay Kit is designed to measure MMP8 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps.
询价产品介绍 The Mouse MCL-1 TR-FRET Assay Kit is designed to measure the inhibition of mouse MCL-1 binding to its ligand in a homogeneous 384 reaction format. This TR-FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple; TR-FRET signal can be measured after 1-hour incubation of a sample containing terbium (Tb)-labeled donor, dye-labeled acceptor, recombinant Mouse MCL-1 protein, peptide ligand, and an inhibitor.
询价背景介绍 Liver-type glutaminase (GLS2) is a phosphate-activated amidohydrolase that catalyzes the hydrolysis of L-glutamine to L-glutamate and ammonia. GLS2 is related to tumor progression and cancer, including breast and hepatocellular carcinoma. 产品介绍 The GLS2 Inhibitor Screening Assay Kit is designed to measure the hydrolase activity of GLS2 for screening and profiling applications.
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The PROTAC Optimization Kit for CDK Kinase-Cereblon Binding is designed for testing and profiling of PROTACs directed against the CDK Kinase family and Cereblon. Cereblon (CRBN) is a Substrate recognition component of the DCX (DDB1-CUL44-Rbx1) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
The CDK inhibitor Palbociclib is included as a control inhibitor of PROTAC binding to CDK. With this kit, only three simple steps on a microtiter plate are required for PROTAC activity detection. First, a sample containing PROTAC is incubated with CRBN and CDK4 or CDK6 Kinase. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
背景介绍 Angiotensin converting enzyme 2 (ACE2) is an exopeptidase that catalyzes the conversion of angiotensin II to angiotensin 1-7 and L-phenylalanine. Angiotensin II is part of the classical renin angiotensin system (RAS), a hormone system that regulates fluid balance, blood pressure and maintains vascular tone. ACE2 has been also proved to be the receptor for the human respiratory coronavirus NL63, the SARS-coronavirus (SARS-CoV) and the novel coronavirus 2019-nCoV/SARS-CoV-2. 产品介绍 The ACE2 Inhibitor Screening Assay Kit is designed to measure the exopeptidase activity of ACE2 for screening and profiling applications.
询价背景介绍 MMP2 (matrix metalloproteinase 2), also known as Gelatinase A, is a member of the matrix metalloproteinase (MMP) family involved in the breakdown of type IV collagen, a major structural component of basement membranes. The activity of MMP2 is associated with cancer cell metastasis and other diseases, including Multicentric Osteolysis, Nodulosis, and Arthropathy. 产品介绍 The Fluorogenic MMP2 Assay Kit is designed to measure MMP2 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 MMP9 (matrix metalloproteinase 9), also known as Gelatinase B, is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. Abnormal expression of MMP9 is observed in many diseases, including cancer and coronary artery disease. The (Q279R) mutation, found within the fibronectin type II domain, is associated with increased risk for in-transit metastasis. 产品介绍 The Fluorogenic MMP9 (Q279R) Assay Kit is designed to measure MMP9 (Q279R) activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 Wee1 is a tyrosine kinase that is overexpressed in many cancer types such as luminal and HER2-positive breast cancer subtypes, hepatocellular carcinomas, and glioblastomas. Wee1 plays a crucial role in regulating the cell division cycle through phosphorylation of CDKs. Inhibiting Wee1 has been shown to prevent the cells from repairing DNA damage due to unchecked replication, suggesting possible combination therapeutics of the DNA damaging reagents and Wee1 inhibitors. 产品介绍 The Wee1 Assay Kit is designed to measure Wee1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent.
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