服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 NEK6 is a protein kinase in the NIMA-related serine/threonine kinase family that plays a role in mitotic cell cycle progression. Overexpression of NEK6 has been linked to many human diseases including liver, breast, lung, stomach, colon, larynx, ovary and prostate cancer, making NEK6 an attractive target for anti-cancer therapeutics. Inhibition of NEK6 has been shown to induce cell death and premature senescence. 产品介绍 The NEK6 Kinase Assay Kit is designed to measure NEK6 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价背景介绍 MMP13 (matrix metalloproteinase 13), also known as collagenase 3, is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP13 primarily cleaves type II collagen, and it is expressed in the skeleton where it plays a role in restructuring the collagen matrix for bone mineralization and cartilage turnover. MMP13 is also overexpressed in rheumatoid arthritis, osteoarthritis, and many human carcinomas, suggesting its potential as a therapeutic target. 产品介绍 The Fluorogenic MMP13 Assay Kit is designed to measure MMP13 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 MMP10 (matrix metalloproteinase 10), also known as Stromelysin-2, is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP10 moderates inflammation by controlling macrophage activation and is linked to several lung disorders, including pulmonary fibrosis and cystic fibrosis. MMP10 has also been shown to cleave the mutant huntingtin protein associated with Huntington's disease. 产品介绍 The Fluorogenic MMP10 Assay Kit is designed to measure MMP10 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As a first step of the viral replication strategy, the virus attaches to the host cell surface before entering the cell. The Spike protein recognizes and binds to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection. 产品介绍 The SARS-CoV-2 IgG detection kit is designed for qualitative detection of human IgG antibodies in serum collected from individuals suspected of prior infection with the virus that causes COVID-19. This fast and simple ELISA uses the receptor binding domain (RBD) of the SARS-CoV-2 Spike protein (BPS Bioscience #100696) to identify IgG antibodies that indicate a previous infection with SARS-CoV-2.
询价背景介绍 MMP1 (matrix metalloproteinase 1) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP1 is also associated with the regulation of cytokines and chemokines, suggesting a role for MMP1 in inflammation. 产品介绍 The Fluorogenic MMP1 Assay Kit is designed to measure MMP1 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 As the viral load increases in the infected individual prior to the onset of symptoms, the individual may unknowingly be able to actively spread the infection during this presymptomatic phase. Once the immune system recognizes the infection, IgM is generated against the virus initially, followed by a second response leading to the production of higher affinity IgG molecules targeting the SARS-CoV-2 virus. IgG antibodies to SARS-CoV-2 generally become detectable beginning 10 - 14 days following infection but may occur later. The presence of IgG antibodies, following previously negative testing defines IgG antibody seroconversion following SARS-CoV-2 infection. False positive results for IgG antibodies may occur due to cross-reactivity from pre-existing antibodies or other possible causes. This assay kit is not intended for clinical diagnostic use. 产品介绍 The SARS-CoV-2 IgG detection kit is designed for qualitative detection of human IgG antibodies in serum collected from individuals suspected of prior infection with the virus that causes COVID-19. This fast and simple ELISA uses the trimeric form of the SARS-CoV-2 Spike protein (BPS Bioscience #100728) to identify IgG antibodies that indicate a previous infection with SARS-CoV-2. The Spike protein is expressed on the viral membrane as a trimer, which means this kit measures IgG antibodies in a more physiologically relevant context than many other commercially available ELISA kits.
询价产品介绍 The activation of naíve T cells requires two signals, the specific T cell receptor recognition of MHC/Antigen on the surface of the antigen-presenting cell (APC), and the binding of B7-1 (CD80) ligand on the APC with the CD28 receptor on the T cell surface. Conversely, binding of CTLA4 to B7-1 on the T-cell surface results in an inhibitory signal and prevents T-cell activation. CTLA4B7-1 interaction is an important drug target for the regulation of the host's response to cancer. The CTLA4 [Biotinylated]:B7-1 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CTLA4:B7-1 signaling. The key to this kit is the high sensitivity of detection of biotin-labeled CTLA4 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, B7-1 is coated on a 96-well plate. Next, CTLA4[B] is incubated with B7-1 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
询价产品介绍 The CRBN Assay Buffer is optimized for use with the Cereblon Binding Assay Kit (BPS Bioscience #79899).
询价背景介绍 Cathepsin F is a lysosomal cysteine protease that belongs to the papain-like superfamily. It is secreted by macrophages and is thought to play a role in processing and loading peptides into MHC complexes. Cathepsin F is also expressed in atherosclerotic lesions, where it degrades ApoB-100, triggering LDL aggregation. It has been implicated in tumor invasion and metastasis, inducing apoptosis of gastric cancer cells, and mutations in cathepsin F have been linked to Alzheimer's disease and Type B Kuf's disease. 产品介绍 The Cathepsin F Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin F for screening and profiling applications.
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