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  • Cathepsin V, His-tag

    规格:10 µg

    产品介绍 Human cathepsin V (GenBank Accession No. NM_001333.2), CD33 signal peptide(a.a. 1-16) + cathepsin V (a.a. 18-334), with C-terminal His-tag, MW=37 kDa, expressed in FreeStyle 293-F cells.

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  • Cathepsin S, His-tag

    规格:10 µg

    产品介绍 Human cathepsin S (GenBank Accession No. NM_004079.3), CD33 signal peptide(a.a. 1-16) + cathepsin S (a.a. 17-331), with C-terminal His-tag, MW=37 kDa, expressed in FreeStyle 293-F cells.

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  • Cathepsin L, His-tag

    规格:10 µg

    产品介绍 Human cathepsin L (GenBank Accession No. NM_001912), a.a. 18-333, with C-terminal His-tag, MW=36 kDa, expressed in FreeStyle 293-F cells.

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  • Cathepsin F, His-tag

    规格:50 µg

    产品介绍 Human cathepsin F (GenBank Accession No. NM_003793), CD33 signal peptide(a.a. 1-16) + cathepsin F (a.a. 20-end), with C-terminal His-tag, MW = 53 kDa (more than 58kDa after post-modification), expressed in FreeStyle 293-F cells.

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  • Cathepsin B, His-tag

    规格:10 µg

    产品介绍 Human cathepsin B (GenBank Accession No. NM_001908), CD33 signal peptide (a.a. 1-16) + CathepsinB (a.a. 18-339), with C-terminal His-tag, MW=43 kDa, expressed in FreeStyle 293-F cells.

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  • SARS-CoV-2 Spike Trimer (S1+S2):ACE2 Inhibitor Screening Colorimetric Assay Kit

    规格:96 reactions

    产品介绍 The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The Spike glycoprotein is expressed on the surface of the virus as a trimer. Each Spike protein consists of two subunits, S1 and S2, and the S1 subunit has a receptor binding domain (RBD) which recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection. The SARS-CoV-2 Spike Trimer (S1+S2) :ACE2 Inhibitor Screening Assay Kit includes the Spike protein in its native trimeric conformation to provide a more physiologically relevant screen for inhibitors of the Spike S1:ACE2 interaction. The SARS-CoV-2 Spike Trimer (S1+S2) :ACE2 Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is that the SARS-CoV-2 Spike Trimer (S1+S2) protein provides a more biologically relevant model than monomeric Spike RBD protein for the investigation of SARS-CoV-2/host cell interaction. Only a few simple steps on a microtiter plate are required for the assay. First, SARS-CoV-2 Spike Trimer (S1+S2) is coated on a 96-well plate. Next, Biotin-ACE2 is incubated with SARS-CoV-2 Spike Trimer (S1+S2) on the plate. Finally, the plate is treated with Streptavidin-HRP followed by addition of a colorimetric HRP substrate to produce color, which then can be quenched and measured using a UV/Vis microplate reader.

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  • PLPro Substrate

    规格:1 mg

    产品介绍 The PLPro (Papain-Like Protease) substrate is a small 5-mer fluorogenic peptide (Z- RLRGG-AMC) used to measure the activity of SARS family PLPro proteases. Release of the C-terminal AMC dye (7-amido-4-methylcoumarin ) by proteolysis generates fluorescence, which can be monitored at an excitation wavelength of 345 nm and an emission wavelength of 445 nm. Conditions optimized for use with: Papain-like Protease (SARS-CoV-2) Assay Kit: Protease Activity (BPS Bioscience #79995). The peptide corresponds to a short sequence of ubiquitin and may also be used as substrate of USP5 (isopeptidase T) and ubiquitin C-terminal hydrolases (UCH family, for example UCHL1).

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  • Papain-like Protease (SARS-CoV-2) Assay Kit: Deubiquitinase Activity

    规格:96 reactions

    背景介绍 Coronaviruses (CoVs) primarily cause multiple respiratory and intestinal infections in humans and animals. Papain-Like Protease (PLPro), also known as PLP, play an essential role in polypeptide processing during virus replication. PLPro, in addition to being crucial during replication via processing of the viral polyprotein, is proposed to be a key enzyme in the sustained pathogenesis of SARS-CoV. This includes deubiquitination (the removal of ubiquitin) from host-cell proteins. The last enzymatic activity result in the antagonism of the host antiviral innate immune response. As a result, PLpro is an important potential target for antiviral drugs that may inhibit viral replication and weaken dysregulation of signalling cascades in infected cells that may lead to cell death in surrounding, uninfected cells. PLPro inhibitors that can block viral replication are promising potential drug candidates that could be used to treat patients suffering with the COVID-19 coronavirus infection. 产品介绍 The Papain-like Protease Assay Kit: Deubiquitinase Activity is designed to measure Papain-like Protease deubiquitinating activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.

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  • MMP14 Fluorogenic Assay Kit

    规格:96 reactions

    背景介绍 MMP14 (matrix metalloproteinase 14) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix.MMP14 regulates the activity of multiple extracellular and plasma membrane proteins, influencing cell-cell and cell-extracellular matrix (ECM) degradation and remodeling, cell invasion, and cancer metastasis. MMP14 is highly expressed in most sarcomas, and levels of MMP14 correlate with breast cancer progression. Upregulation of MMP14 also promotes glioma invasion and tumor cell proliferation and plays a role in angiogenesis. 产品介绍 The Fluorogenic MMP14 Assay Kit is designed to measure MMP14 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.

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