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产品介绍 The NSD2 Chemiluminescent Assay Kit is designed to measure NSD2 activity for screening and profiling applications. The key to the NSD2 Chemiluminescent Activity Assay Kit is a highly specific antibody that recognizes methylated residue of Histone H3. With this kit, only three simple steps are required for methyltransferase detection. First, Sadenosylmethionine is incubated with a sample containing assay buffer and methyltransferase enzyme. Next, primary antibody is added. Finally, the plate is treated with an HRP-labeled secondary antibody followed by addition of the HRP substrate to produce chemiluminescence that can then be measured using a chemiluminescence reader.
询价产品介绍 The NSD3 Chemiluminescent Assay Kit is designed to measure NSD3 activity for screening and profiling applications. The key to the NSD3 Chemiluminescent Activity Assay Kit is a highly specific antibody that recognizes methylated residue of Histone H3. With this kit, only three simple steps are required for methyltransferase detection. First, Sadenosylmethionine is incubated with a sample containing assay buffer and methyltransferase enzyme. Next, primary antibody is added. Finally, the plate is treated with an HRP-labeled secondary antibody followed by addition of the HRP substrate to produce chemiluminescence that can then be measured using a chemiluminescence reader.
询价背景介绍 The methylation of internal adenosines at the N6 position (m6A) in RNA has been shown to play essential roles in various normal and pathologic processes, including various cancers, leukemia, Alzheimer's disease, and obesity. FTO (Fat mass and obesity-associated protein), also known as ALKBH9 and BMIQ14, is the first m6A demethylase identified. 产品介绍 The FTO Chemiluminescent Assay Kit is designed to measure FTO activity for screening and profiling applications. The key to the FTO Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to the activity. With this kit, only three simple steps on a microtiter plate are required for detection of demethylase activity. First, FTO enzyme is incubated with the substrate. Next, primary antibody is added. Finally, the plate is treated with an HRPlabeled secondary antibody followed by the addition of the HRP substrate to produce chemiluminescence that can be measured using a chemiluminescence reader.
询价产品介绍 Human PDPN, known as Podoplanin, GenBank Accession No. NM_006474, a.a. 23-131, with C-terminal Avi-Tag fused to the Fc portion of Human IgG1 and expressed in a HEK293 cell expression system. This protein runs at a higher MW by SDS-PAGE due to glycosylation. MW = 40 kDa.
询价产品介绍 Human secreted CD276, known as Cluster of Differentiation 276 and B7-H3, GenBank Accession No. NM_001024736, a.a. 29466, with C-terminal Avi-His-Tag expressed in a HEK293 expression system. MW = 50 kDa.
询价产品介绍
The 5X Kinase Buffer 1 is optimized for use with a large variety of BPS Bioscience Kinase Assay Kits.
Optimized for Use With:
B-Raf(V600E) Kinase Assay Kit
EGFR Kinase Assay Kit
EGFR(L858R) Kinase Assay Kit
EGFR(T790M) Kinase Assay Kit
EGFR(T790M/L858R) Kinase Assay Kit
FAK Kinase Assay Kit
VEGFR2(KDR) Kinase Assay Kit
背景介绍 Mammalian PTPases can be subdivided into two broad categories: transmembrane receptor PTPases and intracellular PTPases. SHP-2 (PTPN11) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains located at the amino-terminal side of a single PTPase catalytic domain. In the inactive state, the N-terminal SH2 domain interacts with the PTP domain and blocks access of potential substrates to the active site. Upon binding to target phospho-tyrosyl residues, the N-terminal SH2 domain is released from the PTP domain, and the enzyme is activated by relieving this auto-inhibition. SHP-2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. 产品介绍 The Homogeneous full length SHP-2 Assay Kit is a complete assay system designed to measure full length SHP-2 activity for screening and profiling applications. Using this kit, only two simple steps on a microtiter plate are needed to analyze the full length SHP-2 activity level. At the first step, the SHP-2 enzyme is preincubated with SHP-2 Activating Peptide to activate the enzyme. At the second step, the fluorogenic substrate, DiFMUP, is added in the mixture and the enzymatic activity releases DiFMU fluorophore that can then be measured using a fluorescence reader.
询价背景介绍 Mammalian PTPases can be subdivided into 2 broad categories: transmembrane receptor PTPases and intracellular PTPases. SHP-2 (PTPN11) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains that are located at the amino-terminal side of a single PTPase catalytic domain. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. 产品介绍 The Homogeneous SHP-2 Assay Kit is a complete assay system designed to measure SHP-2 activity for screening and profiling applications. Using this kit, only one simple step on a microtiter plate is needed to analyze the SHP-2 activity level. The fluorogenic substrate, DiFMUP, is incubated with purified SHP-2 and the enzymatic activity releases DiFMU fluorophore that can then be measured using a fluorescence reader.
询价产品介绍 Acetyl-Coenzyme A Carboxylase (ACC) plays an important role in fatty acid metabolism so it has been proposed to be a drug target for the fatty acid-related metabolic diseases including obesity and diabetes. The Acetyl-Coenzyme A Carboxylase 1 (ACC1) assay kit is designed to measure ACC1 activity for screening and profiling applications using ADP-Glo™ reagents as a detection reagent
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