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产品介绍 Human CD22 also known as cluster of differentiation-22, and SIGLEC-2, GenBank Accession No. NM_001771, a.a. 100-330 fused to Fc region of Human IgG1 with C-terminal Avi-Tag™. and expressed in a HEK293 cell expression system. MW = 104 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
询价产品介绍 Human Jak2 with W659A, W777A, and F794H mutations, GenBank Accession No. NM_004972, a.a. 536-812, with Cterminal His-Avi-Tag, expressed in an Sf9 cell expression system and enzymatically Biotin-labeled using AviTag™ technology. MW=35 kDa.
询价产品介绍 Mouse TREM2, also known as Triggering receptor expressed on myeloid cells 2 and Trem2a, GenBank Accession No. NM_031254, a.a. 19-168, fused at the C-terminus to the Fc portion of Human IgG1 and with a C-terminal Avi-tag, expressed in a Hek293 expression system. MW=45 kDa.
询价背景介绍 The binding of Programmed Cell Death Protein 1 (PD-1), a receptor expressed on activated Tcells, to its ligands, PD-L1 and PD-L2, negatively regulates immune responses. The PD-1 ligands are found on most cancers, and PD-1:PD-L1/2 interaction inhibits T cell activity and allows cancer cells to escape immune surveillance. The PD-1:PD-L1/2 pathway is also involved in regulating autoimmune responses, making these proteins promising therapeutic targets for a number of cancers, as well as multiple sclerosis, arthritis, lupus, and type I diabetes. 产品介绍 The recombinant expression vectors are designed to express human engineered T cell receptor (TCR) activator and woodchuck (groundhog, Marmota monax) PD-L1 (GenBank Accession #HQ403651) in mammalian cells. The transfected cells can be used in conjunction with Woodchuck PD-1/NFAT Reporter/Jurkat T cells (BPS #79456) to study the interactions of PD-1 with PD-L1 ligand in a cellular context and screen for modulators of this signaling pathway.
询价产品介绍 Human Jak2, also known as Janus kinase-2, Just Another Kinase 2, JAK2-JH2, with V617F mutation, GenBank Accession No. NM_004972, a.a. 1-1132 (end), with C-terminal FLAG-Avi-Tag, expressed in a HEK293 expression system. This protein is enzymatically Biotin-labeled using AviTag™ technology. MW=134 kDa.
询价产品介绍 Human Glutathione S-Transferase Pi 1 (GSTP1), also known as GST Class-Pi, GST3, Fatty Acid Ethyl Ester Synthase III and Deafness X-Linked 7 (DNF7), Genbank Accession No. NM_000852, a.a. 2-211(end) with N-terminal His-FLAG-tags, expressed in an E. coli expression system. MW=26 kDa.
询价产品介绍 Rat CERK, also known as ceramide kinase, GenBank Accession No. NM_00113486, 1-531 (end) with C-terminal Flag tag, MW= 61 kDa, expressed in baculovirus expression system.
询价产品介绍 Mouse CERK, also known as ceramide kinase, GenBank Accession No. NM_00113486, 1-531 (end) with C-terminal Flag tag, MW= 61 kDa, expressed in baculovirus expression system.
询价产品介绍 Sortases catalize a transpeptidation reaction, where the enzyme cleaves the amide bond between the threonine and glycine of the sortase recognition sequence (LPXTG for S. aureus Sortase A), generating a thioacyl intermediate. Subsequently, this intermediate is resolved by the N-terminus of an oligoglycine nucleophile, creating a new peptide bond that links the substrate to the incoming nucleophile. The Sortagging Kit takes advantage of this reaction to label virtually any recombinant antibody or protein containing the sortase recognition sequence. Labeling efficiency of greater than 90% is achieved by taking advantage of the highly active Sortase 5Δ Pentamutant. Simply combine your protein of interest with Sortase 5Δ and a polyglycine label, and incubate for 1 hour at 37°C. Purification columns are included to remove Sortase 5Δ and excess label. The kit also includes Ubiquitin-LPETGH6 and GGG-Clover as positive controls.
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