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产品介绍 The 4x Detection Buffer is optimized for use with the PRMT5 Homogeneous Assay Kit (BPS Bioscience #52052).
询价产品介绍 Human B7-H6, also known as NCR3LG1, B7 homolog 6, and natural killer cell cytotoxicity receptor. GenBank Accession No. NM_001202439, a.a. 25-262 with C-terminal Fc-Avi-Tag, expressed in a HEK293 cell expression system. This protein was biotinylated using AviTag™ technology. MW = 52 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
询价产品介绍 Human B7-H6, also known as NCR3LG1, B7 homolog 6, and natural killer cell cytotoxicity receptor. GenBank Accession No. NM_001202439, a.a. 25-262 with C-terminal Fc-Avi-Tag, expressed in a HEK293 cell expression system. MW = 52 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
询价产品介绍 Human Jak2 with V617F mutation, GenBank Accession No. NM_004972, containing the catalytic and the pseudo kinase domain (a.a. 513-1132 (end)), with N-terminal GST-Tag, expressed in a HEK293 expression system. MW=99 kDa.
询价背景介绍 Colony Stimulating Factor 1 Receptor (CSF1R, CD115, M-CSF-R) is the receptor for the cytokine CSF1 (MCSF; CSF-1), which controls the growth, function, and differentiation of macrophages. This interaction drives the development and survival of Tumor-Associated Macrophages (TAMs), which in turn suppress the local immune response to the cancer. An alternative ligand is IL-34, which has been implicated in neuroprotective and survival signals following brain injury and neurodegeneration. As a tyrosine kinase transmembrane receptor, activation of CSF1R by its ligand initiates a vast array of intracellular activity, including activation of the MAPK/ERK signaling pathway. When phosphorylated by ERK, Elk1 forms a complex with Serum Response Factor (SRF) and binds to Serum Response Element (SRE), resulting in the expression of numerous mitogen-inducible genes. 产品介绍 The CSF1R SRE Reporter Kit is designed for monitoring the activity of the CSF1R signaling pathway in cultured cells. The kit contains a transfection-ready vector for CSF1R and SRE luciferase reporter vector. Upon ligand binding, active CSF1R will initiate the MAPK/ERK signaling pathway, leading to expression of the SRE-controlled reporter. This reporter contains the firefly luciferase gene under the control of multimerized SRE responsive elements located upstream of a minimal promoter. The SRE reporter is premixed with a constitutively-expressing Renilla luciferase vector that serves as an internal control for transfection efficiency. The kit also includes a non-inducible firefly luciferase vector premixed with constitutively- expressing Renilla luciferase vector as a negative control. The non-inducible luciferase vector contains the firefly luciferase gene under the control of a minimal promoter, without any additional response elements. The negative control is critical for determining pathway-specific effects and the background luciferase activity.
询价背景介绍 Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been reported in a multitude of human cancers. While the wild type IDH1, produces α-ketoglutarate (α-KG) through the reduction of NADP+ to NADPH, the IDH1(R132H) mutant catalyzes conversion of α-ketoglutarate to 2-hydroxy-glutarate (2-HG) by oxidizing NADPH to NADP+. Genomic studies have identified the IDH1(R132H) mutation in various cancer types, including glioma, chondrosarcoma, and AML as well as a small percentage of prostate, lung and colon cancers. 产品介绍 The IDH1(R132H) Assay Kit is designed to measure IDH1(R132H) activity for screening and profiling applications by measuring NADPH consumption.
询价产品介绍 Human CD28 homolog (CD28H), also known as Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2) and immunoglobulin and prolinerich receptor 1 (IGPR-1). GenBank Accession No. NM_144615, a.a. 23-150 with C-terminal His-Tag expressed in a HEK293 expression system. MW = 15 kDa.
询价产品介绍 Human B7-H7, also known as HHLA2, HERV-H LTR-associating 2, GenBank Accession No. NM_007072, a.a. 23-344, with a C-terminal Avi-Tag fused with the Fc portion of Human IgG1, expressed in a HEK293 cell expression system. MW =66 kDa.
询价产品介绍 Human TNFR2 protein, also known as tumor necrosis factor receptor 2, TNFRSF1B, and CD120b, with C-terminal His-Avi™-Tag fused to the Fc region of Human IgG1. GenBank Accession No. NM_001066, a.a. 23-257 expressed in a HEK293 cell expression system. MW = 55 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
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