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背景介绍 The estrogen receptor alpha (ERalpha, UniProt/Swiss-Prot entry P03372) belongs to the family of nuclear hormone receptors, which are ligand-activated transcription factors. They are important for the regulation of gene expression, cellular proliferation and differentiation, sexual development and reproductive function. Estrogen receptors are also involved in pathological processes such as breast cancer, and osteoporosis. ERalpha can regulate transcription by direct binding to estrogen response elements (EREs) in the DNA or by interaction with other transcription factors. It may also form a heterodimer with ERbeta. 产品介绍 Monoclonal antibody raised in mouse against human ERalpha (estrogen receptor alpha), using a synthetic peptide
询价背景介绍 EHMT1 (UniProt/Swiss-Prot entry Q9H9B1) is a histone methyltransferase which specifically methylates histone H3 on lysine 9. H3K9 methylation represents a marker for epigenetic transcriptional repression. This repression is established by recruiting HP1 proteins to the methylated histone. H3K9 methylation may contribute to silencing of MYC and E2F responsive genes and plays a role in murine embryogenesis. 产品介绍 Polyclonal antibody raised in rabbit against mouse Ehmt1 (euchromatic histone-lysine N-methyltransferase 1), using three KLH-conjugated synthetic peptides containing a sequence from the central part of the protein
询价背景介绍 DNMT3B (UniProtKB/Swiss-Prot entry Q9UBC3) catalyses the genome wide de novo methylation of CpG residues, which regulates gene expression. DNMT3B is essential for development. DNA methylation on CpG residues is coordinated with methylation of histones. Six different isoforms of DNMT3B, produced by alternative splicing, exist although isoforms 4 and 5 may not be functional due to the absence of two conserved methyltransferase motifs. 产品介绍 Polyclonal antibody raised in rabbit against mouse DNMT3B (DNA methyltransferase 3B), using 3 KLHconjugated synthetic peptides containing sequences from different parts of the protein.
询价背景介绍 DNMT3A (UniProtKB/Swiss-Prot entry Q9Y6K1) catalyses the genome wide de novo methylation of CpG residues. DNA methylation on CpG residues by DNMT3A regulates gene expression and is essential for development. DNMT3A is strongly expressed in embryonic stem cells, but low in adult somatic cells. DNA methylation is coordinated with methylation of histones. DNMT3A binds to SETDB1 and HDAC1, and is involved in the repression of transcription from promoters containing an E2F binding site. 产品介绍 Polyclonal antibody raised in rabbit against human DNMT3A, (DNA methyltransferase 3A), using a KLH-conjugated synthetic peptide corresponding to amino acids 92-106.
询价背景介绍 DNMT2 (UniProtKB/Swiss-Prot entry O14717) belongs to the family of DNA cytosine methyltransferases. DNMT2, however, lacks the large N-terminal regulatory domain common to other eukaryotic methyltransferases and does not methylate CpG in genomic DNA. Instead, it specifically methylates cytosine 38 in the anticodon loop of Asp transfer RNA. 产品介绍 Polyclonal antibody raised in rabbit against mouse DNMT2 (DNA methyltransferase 2), using a KLHconjugated synthetic peptide containing an amino acid sequence from the N-terminal part of the protein
询价背景介绍 DNMT1 (UniProt/Swiss-Prot entry P26358) preferentially methylates CpG residues in hemimethylated DNA and is responsible for maintaining methylation patterns established in development. Inactivation of DNMT1 causes global demethylation and embryonic lethality. DNA methylation is coordinated with methylation of histones. Transcriptional repression by DNMT1 is mediated by direct interaction with HDAC2 产品介绍 Polyclonal antibody raised in rabbit against mouse DNMT1 (DNA (cytosine-5)-methyltransferase 1), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the C-terminal part of the protein
询价背景介绍 Cre recombinase originates from bacteriophage P1 and recognizes loxP sites in the genome. It catalyzes recombination between two loxP sites, thereby excising the intervening DNA sequence. Cre recombinase is used as a tool for the generation of transgenic animals 产品介绍 Polyclonal antibody raised in rabbit against Cre recombinase using a KLH-conjugated synthetic peptide located at the C-terminal part of the protein
询价背景介绍 CHD1 (UniProtKB/Swiss-Prot entry O14646) is an ATP-dependent chromatin remodeling factor, containing two tandem chromodomains. In human both chromodomains are essential for specific binding to histone H3, methylated at lysine 4. CHD1 belongs to the SNF2/RAD54 helicase family and contains also one helicase ATP-binding domain and one helicase C-terminal domain. It may play an important role in gene regulation. 产品介绍 Polyclonal antibody raised in rabbit against human CHD1 (Chromodomain helicase DNA binding protein 1), using a GST-fused recombinant protein.
询价背景介绍 CBX2 (UniProtKB/Swiss-Prot entry Q14781) is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodelling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. CBX2 also is involved in sexual development, acting as an activator of NR5A1 expression. 产品介绍 Polyclonal antibody raised in rabbit against mouse CBX2 (chromobox homolog 2) using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein
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