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产品介绍 Polyclonal antibody raised in rabbit against the region of histone H2A containing the acetylated lysine 5 (H2AK5ac), using a KLH-conjugated synthetic peptide.
询价产品介绍 Polyclonal antibody raised in rabbit against the region of histone H2A containing the ubiquitinylated lysine 119 (H2AK119ub), using a KLH-conjugated synthetic peptide
询价背景介绍 Acetylation of the histone H2A variant H2A.Z is associated with the promoters of active genes 产品介绍 Polyclonal antibody raised in rabbit against histone H2A.Z acetylated at lysines 5, 7 and 11, using a KLH-conjugated synthetic peptide.
询价产品介绍 Polyclonal antibody raised in rabbit against the region of histone H2A.X containing the phosphorylated serine 139 (H2A.XS139p), using a KLH-conjugated synthetic peptide
询价背景介绍 Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a central role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes. 产品介绍 Polyclonal antibody raised in rabbit against histone H2A using a KLH-conjugated synthetic peptide containing an unmodified sequence from the C-terminal part of the protein.
询价背景介绍 Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". 产品介绍 Polyclonal antibody raised in rabbit against histone H1.0, using a KLH-conjugated synthetic peptide.
询价背景介绍 G9a (UniProtKB/Swiss-Prot entry Q96KQ7) is a member of the Set 1 family of histone methyltransferases. It preferentially methylates K9 and K27 of histone H3. Methylation of H3K9 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. G9a is a part of the E2F6.com-1 complex. 产品介绍 Polyclonal antibody raised in rabbit against mouse G9a (Protein G9a), using two KLH-conjugated synthetic peptides containing an amino acid sequence from the central part of the protein.
询价背景介绍 EZH2 (UniProt/Swiss-Prot entry Q15910) is a histone-lysine methyltransferase which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression. It is a member of the polycomb group (PcG) family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex (EED, SUZ12/JJAZ1, RBBP4 and RBBP7). EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer. 产品介绍 Polyclonal antibody raised in rabbit against the N-terminus (aa1-343) of the mouse EZH2 protein (Enhancer of zeste homolog 2).
询价背景介绍 EZH2 (UniProt/Swiss-Prot entry Q15910) is a histone-lysine methyltransferase which methylates Lys-9 and Lys-27 of histone H3, leading to transcriptional repression. It is a member of the polycomb group (PcG) family which form multimeric protein complexes and are involved in maintaining the transcriptional repressive state of genes over successive cell generations. The EZH2 activity is dependent on the association with other components of the PRC2 complex (EED, SUZ12/JJAZ1, RBBP4 and RBBP7). EZH2 may play a role in the hematopoietic and central nervous systems. Over-expression of EZH2 is observed during advanced stages of prostate cancer and breast cancer. 产品介绍 Monoclonal antibody raised in mouse against the central part of the human EZH2 protein (Enhancer of zeste homolog 2)
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