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背景介绍 Ataxin 3-like is highly homologous to ataxin3; yet no homolog has yet been found in an organism other than humans. Ataxin 3-like contains a josephin domain and can cleave ubiquitin-AMC in vitro. 产品介绍 Human Ataxin3-Like recombinant protein, full length, with His-tag, expressed in E. coli.
询价背景介绍 AMSHcore (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSHcore mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. AMSHcore contains only the core domain of AMSH protein. 产品介绍 Human AMSH Core Domain recombinant protein, a.a. 250-424, with His-tag, expressed in E. coli.
询价背景介绍 AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR). Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM. 产品介绍 Human AMSH recombinant protein, full length, with His-tag, expressed in E. coli.
询价背景介绍 Praja1 (along with Praja2, 53% identity) is a RING-H2 domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. Substrates for Praja1 include Dlxin-1 (MAGE-D1, human) which regulates Dlx5 dependent transcriptional function (involved in osteoblast differentiation) and ELF and Smad3 involved in the TGF-beta signaling pathway implicated in gastrointestinal cancers. 产品介绍 Human Praja1 recombinant protein (Genbank Accession No. NP_660095), full length with N-terminal SUMO-tag, expressed in E. coli.
询价背景介绍 MuRF3 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. MuRF3 has been demonstrated to function with the E2 enzyme UBE2D3 (UbcH5c) in vitro. MuRF3 is also known as TRIM54 (tripartite motif containing 54) containing a RING-finger/B-box/coiled-coil tripartite fold. MuRF3 has been implicated along with MuRF1 as regulators of protein degradation in striated muscle. MuRF3 also plays important roles in maintaining cardiac function after myocardial infarction. 产品介绍 Human MuRF3 recombinant protein (Genbank Accession No. Q9BYV2), full length with N-terminal SUMO (variant 3)- and His-tags, expressed in E. coli.
询价背景介绍 MuRF2 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. MuRF2 has been demonstrated to function with the E2 enzyme UBE2D3 (UbcH5c) in vitro. MuRF2 is also known as TRIM55 (tripartite motif containing 55) containing a RING-finger/B-box/coiled-coil tripartite fold. MuRF2 has been implicated along with MuRF1 as regulators of protein degradation in striated muscle. 产品介绍 Human MuRF2 recombinant protein (Genbank Accession No. Q5PQN5), full length with N-terminal SUMO (variant 3) -tag, expressed in E. coli.
询价背景介绍 MuRF1 (Muscle-specific RING-finger protein 1) is an E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates along with E1 and E2 enzymes. MuRF1 is also known as TRIM63 (tripartite motif containing 63) containing a RING-finger/B-box/coiled-coil tripartite fold and is a member of the RING-domain E3 family. MuRF1 has been implicated as a component of atrophy-associated accelerated proteolysis. It is upregulated in a number of different models of atrophy and interacts with numerous myofibrillar proteins. 产品介绍 Human MuRF1 recombinant protein (Genbank Accession No. NP_115977), full length with N-terminal SUMO (variant 3) and His-tags, expressed in E. coli.
询价背景介绍 Hrd1 is a RING domain E3 ligase that is involved in the conjugation of ubiquitin to target substrates. Hrd1 has been demonstrated to function with the E2 enzymes UBE2D3 (UbcH5c) and UBE2G2 in vitro. Hrd1 is an ER-associated ligase involved in ERAD and has been linked to rheumatoid arthritis. It is present in human rheumatoid synovial cells and found to be a causative factor for arthropathy in in vivo studies. Hrd1 is also found in brain neurons and its proper regulation may be linked to neurodegenerative diseases. This construct is a Hrd1 N-terminal deletion containing residues 246-617 consisting of the complete C-terminal cytoplasmic portion. The N-terminal transmembrane spanning portion has been deleted. This Hrd1 N-terminal deletion mutant is active as an E3 ligase containing the RING and substrate recognition domains. 产品介绍 Cytoplasmic region of human Hrd1 recombinant protein (Genbank Accession No. ), a.a. 236-17, with N-terminal SUMO-tag, expressed in E. coli.
询价背景介绍 CARP2 (caspase 8/10 associated RING protein 2) is a RING-domain E3 (ubiquitin protein ligase) that is involved in the conjugation of ubiquitin to target substrates, along with E1 and E2 enzymes. CARPs (CARP1 and CARP2, 77% identity) also belong to the IAP family (inhibitors of apoptosis proteins) inhibiting activation of DED (death effector domain) containing caspase proteins (8 and 10). In addition to targeting caspases 8 and 10, CARPs have been shown to target phosphorylated p53 for degradation in an Hdm2 independent manner. Furthermore, CARP2 has been shown to be a negative regulator of TNF induced NF-κappaB activation by targeting RIP for degradation. 产品介绍 Human CARP2 recombinant protein (Genbank Accession No. NP_476519), full length with N-terminal SUMO- and His-tags, expressed in E. coli.
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