服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 USP33 was originally identified as a protein that interacts with the E3 ubiquitin ligase pVHL, a region commonly mutated in patients with pVHL disease and has been shown to be ubiquitylated by the pVHL E3 ligase complex in vitro and in transiently transfected COS-7 cells. The USP33 catalytic core spans amino acids 181-712. 产品介绍 Human USP33 Core Domain recombinant protein (Genbank Accession No. Q8TEY7), a.a. 181-712, with N-terminal SUMO- and His-tags, expressed in E. coli.
询价背景介绍 Ubiquitin Specific Protease 21 reglulates transcription initiation via deubiquitinylation of histone H2A and exhibits both deubiquitinylase and deNEDDylase activities. 产品介绍 Human USP21 recombinant protein (Genbank Accession No. Q9UK80), with N-terminal SUMO- and His-tags, expressed in E. coli.
询价背景介绍 USP15 is a deubiquitylase that associates with the COP9 signalosome (CSN) complex. It is able to regulate the NF-κappaB pathway by deubquitylating IkappaBalpha2. 产品介绍 Human USP15 recombinant protein, with N-terminal SUMO- and His-tags, expressed in E. coli.
询价背景介绍 UCHL5 (UCH37) is the only ubiquitin carboxy-terminal hydrolase (UCH)-family protease, that is associated with mammalian proteasomes. It is responsible for the ubiquitin isopeptidase activity in the PA700 (19S) proteasome regulatory complex. 产品介绍 Human UCH-L5 recombinant protein, with N-terminal SUMO- and His-tags, expressed in E. coli.
询价背景介绍 A novel virulence factor was identified in Salmonella enterica serovar Typhimurium.This factor was determined to be a protein named SseL.SseL is translocated from the bacteria into the infected cell by a type III secretion system.SseL has de-ubiquitylating activity in vitro and a infection of cells with a SseL mutant leads to an accumulation of ubiquitylated proteins.This mutant strain also fails to cause macrophage cell death which has been implicated in the spread and systemic infection of Salmonella.Other serovars, including Typhi, Paratyphi A and Choleraesuis contain sequences encoding a protein nearly identical to SseL suggesting that de-ubiquitylating enzymes play an important role in the pathogenesis of other Salmonella serovars. 产品介绍 Salmonella Ssel recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 SENP6 is a SUMO/sentrin specific protease that functions to remove SUMO from conjugated proteins. SENP6 has been shown to deSUMOylate a member of the ligand-activated transcription factores called retinoid X receptor alpha. The transcriptional activity of RXRalpha is regulated by SUMOylation. Researchers have demonstrated that SENP6 has a preference for SUMO2/3 conjugates over SUMO1 conjugates. 产品介绍 Human SENP6 Core Domain recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 SUMO Protease 2, a highly active and robust recombinant protease, cleaves hSUMO3 from recombinant fusion proteins. Unlike thrombin, EK, or TEV protease, which recognize short, linear sequences, SUMO Protease 2 recognizes the tertiary structure of huSUMO3. As a result, SUMO Protease 2 will not cleave within the fused protein of interest. 产品介绍 Human SENP2 recombinant protein, with N-terminal His-tag, expressed in E. coli.
询价背景介绍 SUMO Protease 2, a highly active and robust recombinant protease, cleaves hSUMO3 from recombinant fusion proteins. Unlike thrombin, EK, or TEV protease, which recognize short, linear sequences, SUMO Protease 2 recognizes the tertiary structure of huSUMO3. As a result, SUMO Protease 2 will not cleave within the fused protein of interest. 产品介绍 Human SENP2 recombinant protein, with N-terminal His-tag, expressed in E. coli.
询价背景介绍 SENP1 is a SUMO isopeptidase that plays a critical role in the development of prostate cancer. SENP1 is overexpressed in prostate cancer samples and transgenic overexpression of SENP1 in the prostate of mice leads to the development of prostatic intraepithelial neoplasia at an early age.Consistent with the model stated above, investigators have demonstrated that overexpression of SENP1 enhances androgen-receptor mediated transcription. Inactivation of SENP1 in mice by retroviral insertional mutation is embryonic lethal (e12.5-e14.5) and leads to an increase in the steady-state levels of SUMOylated forms of a number of proteins.Depletion of SENP1 levels in PC3 cells by RNAi leads to a decrease in cyclin D1 expression.Transgenic overexpression of SENP1 in the prostate of mice leads to neoplasia at an early age.All of these experiments demonstrate that SENP1 plays a crucial role in the growth and development of organisms.Reinforcing the potential role SENP1 may play in prostate cancer is the observation that SENP1 is overexpressed in many prostate cancer samples. 产品介绍 Human SENP1 Core Domain recombinant protein, with His-tag, expressed in E. coli.
询价
