服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 To date, five human coronaviruses (CoV) have been identified including severe acute respiratory syndrome (SARS).The SARS epidemic of 2002/ 2003 spread to more than 30 countries and had fatality rate of nearly 10%. The SARS genome encodes a number of proteases including papain like protease (PLpro) . Initially, it was reported that SARS PLpro was a deubiquitylase, however subsequent work has shown that PLpro is preferentially a deISGylase. PLpro cleaves ISG15-PLA2 and Ub-PLA2 with high and low efficiency respectively. 产品介绍 SARS Coronavirus PLPro recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 To date, five human coronaviruses (CoV) have been identified including the common human respiratory pathogen NL63, that has been shown to be associated with both upper and lower respiratory tract disease such as bronchiolitis and croup.The prevalence of NL63 infections is illustrated by epidemiological studies reporting that NL63 CoV was detected in 0.3-10% of clinical specimens from both adults and infants diagnosed with respiratory tract diseases. The NL63 genome encodes two papain like proteases, PLP1 and PLP2. PLP2 is a dual specificity isopeptidase with both deubiquitylase and deISGylase activity. PLP2 cleaves Ub-PLA2 and ISG15-PLA2 with high and moderate efficiency respectively. 产品介绍 NL63 Coronavirus PLP2 recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 Otubain 2 is a member of the OTU (ovarian tumor) superfamily of ubiquitin isopeptidases. It was originally identified as a protein capable of binding ubiquitin aldehyde. Researchers have shown that it is able to cleave tetra-ubiquitin chains in vitro only after removal of a 5 residue C-terminal extension. 产品介绍 Human Otub2 recombinant protein (Genbank Accession No. Q96DC9), with His-tag, expressed in E. coli.
询价背景介绍 Otubain 1 is a member of the OTU (ovarian tumor) class of ubiquitin isopeptidases. It was originally identified as a protein capable of binding ubiquitin aldehyde.Researchers have shown that it is able to cleave K48-linked ubiquitin chains in vitro.Otubain 1 has been shown to be involved in T cell function and is a substrate for Yersinia protein kinase. 产品介绍 Human Otub1 recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 The NEDD8 activating E1 enzyme is a heterodimer composed of APPBP1 and UBA3 subunits. The APPBP1/UBA3 enzyme has homology to the N- and C-terminal halves of the ubiquitin E1 enzyme, respectively. The UBA3 subunit contains the catalytic center and activates NEDD8 in an ATP-dependent reaction by forming a high-energy thiolester intermediate. The activated NEDD8 is subsequently transferred to the UbcH12 E2 enzyme, and is then conjugated to specific substrates in the presence of the appropriate E3 ligases. 产品介绍 Human NEDD8 E1 recombinant protein complex, with His-tagged APPBP1 and untagged Uba3, co-expressed in E. coli.
询价背景介绍 Josephin Domain containing protein 2 has deubiquitylating activity in vitro. 产品介绍 Human JosD2 recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 Josephin Domain containing protein 1 has deubiquitinase activity in vitro. 产品介绍 Human JosD1 recombinant protein, with His-tag, expressed in E. coli.
询价背景介绍 DEN1 (SENP8, NEDP1) is a deNEDDylase that deconjugates NEDD8 conjugates. A recent study demonstrated that DEN1 deNEDDylated the tumor suppressor breast cancer-associated protein BCA3. Full length DEN1 cleaves NEDD8-PLA2 with high efficiency. 产品介绍 Human Den1 recombinant protein, with GST-tag, expressed in E. coli.
询价背景介绍 BAP1 is the first large, nuclear-localized UCH to be identified. It is a protein of 90 kDa that binds to the BRCA RING finger and enhances BRCA1-mediated cell growth suppression. 产品介绍 Human Bap1 recombinant protein, with His-tag, expressed in E. coli.
询价
