IRS1-tide

产品介绍 Ready to use Kinase substrate (10X) IRS1-tide is a peptide derived from the sequence motif of the insulin receptor substrate-1.

Human VEGF165 (E. coli derived)

产品介绍 Recombinant human vascular endothelial growth factor (VEGF)165 expressed in E. coli cells. Human VEGF exists in multiple molecular variants and are named based on the number of amino acids they contain. VEGF165 is the most common form of VEGF. It is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptides.

LATS1, GST-Tag

背景介绍 LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding (1). LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments (2). 产品介绍 Human LATS1 protein with N terminal GST-Tag, GenBank Accession No. NM_004690, a.a 589-end, expressed in an Sf9 expression system. MW = 95 kDa.

Anti-β-Tubulin (BT7R)

EGFR (C797A), GST-Tag

背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with C797A mutation. Genbank Accession NM_005228, a.a. 695 end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 87 kDa.

EGFR (T790M C797S), GST-Tag

背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with mutations at T790M and C797S. Genbank Accession NM_005228, a.a. 668 end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 100 kDa.

EGFR, INS P772-NPH-H773, GST-Tag

背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with NPH insertion between P772 and H773. Genbank Accession NM_005228, a.a. 695 end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 90 kDa.

EGFR (L861Q), GST-Tag

背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with L861Q mutation. Genbank Accession NM_005228, a.a. 695 end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 89 kDa.

EGFR (L747S), GST-Tag

背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with L747S mutation. Genbank Accession NM_005228, a.a. 695 end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 89 kDa.