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背景介绍 PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to the ectodomain of hepatic low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. 产品介绍 The PCSK9[Biotinylated]-LDLR Binding Assay Kit is designed for screening and profiling purposes. The key to this kit is the high sensitivity of detection of biotin-labeled PCSK9 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, LDLR ectodomain is coated on a 96-well plate. Next, PCSK9 is incubated with LDLR on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
询价产品介绍 Mouse secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7-H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus with the Fc portion of mouse IgG2a, expressed in a HEK293 cell expression system. MW = 53 kDa.
询价产品介绍 Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein with R-Phycoerythrin-label, also known as CD274 and B7 homolog 1 (B7-H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus with the Fc portion of mouse IgG2a, expressed in a HEK293 cell expression system. MW = 53 kDa.
询价产品介绍 Human secreted programmed cell death 1 (PD-1)-Fc fusion protein, also known as, PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a 25-167, fused at the C-terminus to the Fc portion of Mouse IgG2a, expressed in a HEK293 cell expression system. MW = 43 kDa.
询价产品介绍 Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7-H1) with a K124A mutation, GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus with the Fc portion of human IgG1, with C-terminal Avi-tag™ expressed in a HEK293 cell expression system. MW = 54 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
询价产品介绍 Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7-H1) with a Y123A mutation, GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus with the Fc portion of human IgG1, with C-terminal Avi-tag™ expressed in a HEK293 cell expression system. MW = 54 kDa. This protein runs at a higher MW by SDS-PAGE due to glycosylation.
询价产品介绍 Recombinant human CD38 (CD38 molecule) encompassing amino acids 43 to 300 (end). This construct contains a C-terminal His-tag (6xHis). The recombinant protein was affinity purified and labeled with APC.
询价产品介绍 Human CD38, also known as cluster of differentiation 38, ADP-Ribosyl Cyclase 1, NAD(+) Nucleosidase, and ADPRC 1, GenBank Accession No. NM_001775, a.a. 43-300 with C-terminal His-tag, expressed in a HEK293 cell expression system and labeled with phycoerythrin (PE). MW=31 kDa.
询价产品介绍 Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein with R-Phycoerythrin-label, also known as CD274 and B7 homolog 1 (B7-H1), GenBank Accession No. NM_014143, amino acids 19-239, fused at the C-terminus with the Fc portion of human IgG1, expressed in a HEK293 cell expression system. MW = 53 kDa.
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