服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
产品介绍 The 3CL Protease (MERS-CoV) Assay Buffer is optimized for use with the 3CL Protease (MERS-CoV) Assay Kit (BPS Bioscience #78023).
询价背景介绍 MMP11 (matrix metalloproteinase 11), also known as Stromelysin-3 (SL-3), is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP11 was initially discovered in breast carcinoma and has since been identified in diverse carcinomas and developmental processes. MMP-11 promotes cancer development by inhibiting apoptosis as well as enhancing migration and invasion of cancer cells. MMP11 is activated by furin, an enzyme linked to the entry of the SARS-CoV-2 virus into cells. 产品介绍 The Fluorogenic MMP11 Assay Kit is designed to measure MMP11 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 FLT1 is a protein kinase in the src gene family that plays a role in mitotic cell cycle progression. Alteration of FLT1 has been shown in various cancers such as breast carcinoma and melanoma. 产品介绍 The FLT1 Kinase Assay Kit is designed to measure FLT1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价产品介绍
The pandemic coronavirus disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). As a first step of the viral replication strategy, the virus attaches to the host cell surface before entering the cell. The Receptor Binding Domain (RBD) of Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection.
The Spike RBD (SARS-CoV-2):ACE2 Inhibitor Screening Colorimetric Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is the high sensitivity of detection of ACE2-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, Spike RBD protein is attached to a 96-well transparent plate. Next, ACE2-Biotin is incubated with Spike RBD on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce color, which can then be measured using a UV/Vis spectrophotometer microplate reader.
背景介绍 MMP12 (matrix metalloproteinase 12) is a member of the matrix metalloproteinase (MMP) family involved in the degradation of the extracellular matrix. MMP12 is also associated with the regulation of cytokines and chemokines, suggesting a role for MMP12 in inflammation. MMP12 is also essential for arterial stiffening in mice and is a highly prognostic marker of arterial stiffness, making MMP12 a therapeutic target for cardiovascular disease. 产品介绍 The Fluorogenic MMP12 Assay Kit is designed to measure MMP12 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 Coronaviruses (CoVs) primarily cause multiple respiratory and intestinal infections in humans and animals. Severe acute respiratory syndrome (SARS) is a highly contagious and often fatal viral respiratory illness caused by a coronavirus called SARS-CoV. It is highly homologous to SARS-CoV-2, the causative agent for COVID-19. The 3CL protease, also known as Main Protease (Mpro), plays a vital role in processing the polyproteins that are translated from the viral RNA. 3CL Protease inhibitors that can block viral replication are promising potential drug candidates that could be used to treat patients suffering with the coronavirus infection. 产品介绍 The 3CL Protease Assay Kit is designed to measure 3CL Protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps. 3CL inhibitor GC376 is also included as an inhibitor control.
询价背景介绍 IL-23A is a pro-inflammatory cytokine that plays a key role in inflammation, autoimmunity, and host defense. Due to its role as a mediator of inflammation, the IL-23 pathway has become a popular target for treating diseases that have a strong inflammatory component such as bowel disease and colon cancer. 产品介绍 The IL-23RA:IL-23A[Biotin] Inhibitor Screening Assay Kit is designed for screening inhibitors of IL-23A:IL-23RA interaction. The key to this kit is the high sensitivity of detection of biotin-labeled IL-23A by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, IL-23RA is coated on a 96-well plate. Next, IL-23A[Biotin] is incubated with IL-23RA on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
询价产品介绍 GC376 a 3CL protease inhibitor is optimized for use with the 3CL Protease (SARS-CoV-2) Assay Kit (BPS Bioscience #79955) and 3CL Protease (SARS-CoV) Assay Kit (BPS Bioscience #78015).
询价产品介绍
Severe acute respiratory syndrome (SARS) is a viral respiratory illness caused by a corona virus called SARS-CoV-1. It was first reported in February 2013 in Asia and the epidemic affected ~ 26 countries and resulted in more than 8000 deaths. Like SARS-CoV-2, SARS-CoV-1 Spike protein recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-1 and ACE2 may offer some protection against the viral infection. The SARS-CoV-1 Spike Trimer (S1+S2):ACE2 Inhibitor Screening Assay Kit includes the SARS-CoV-1 Spike protein in its native trimeric conformation to provide a more physiologically relevant screen for inhibitors as well as a compatible platform to investigate the specificity of SARS-CoV-2:ACE2 inhibitors.
The key to this kit is that the SARS-CoV-1 Spike Trimer (S1+S2) protein provides a more biologically relevant model than monomeric Spike RBD protein for the investigation of SARS-CoV-1/host cell interaction. Only a few simple steps on a microtiter plate are required for the assay. First, SARS-CoV-1 Spike Trimer (S1+S2) is coated on a 96-well plate. Next, Biotin-ACE2 is incubated with SARS-CoV-1 Spike Trimer (S1+S2) on the plate. Finally, the plate is treated with Streptavidin-HRP followed by addition of a colorimetric HRP substrate to produce color, which then can be quenched and measured using a UV/Vis microplate reader.
