服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 Human Ataxin-3 (ATX3 or ATXN3), also known as Josephin (JOS) or Machado-Joseph disease protein 1 (MJD1), is implicated in Machado-Joseph disease, a neurological disease that progresses cerebellar ataxia. It is also clinically relevant in gastric, lung, and testicular cancers. 产品介绍 The Ataxin-3 Fluorescent Assay Kit is designed to measure Ataxin-3 activity for screening and profiling applications, in a homogeneous assay with no timeconsuming washing steps.
询价背景介绍 Furin is a member of the proprotein convertase (PC) family, which belongs to the subtilisin superfamily of serine protease. This protease is thought to cleave and activate more than 150 mammalian, viral and bacterial substrates. Among them are viral envelope glycoproteins and bacterial toxins, as well as cellular factors that can promote tumor development and growth. Cleavage of the SARS coronavirus spike glycoprotein by Furin is a critical step in viral fusion and entry, making furin a potential target for SARS-CoV-2 therapy. 产品介绍 The Furin Protease Assay Kit is designed to measure Furin Protease activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 AKT1, also known as Protein Kinase B Alpha (PKBα), is a serine/threonine kinase found in various cell types throughout the body, where it plays a critical role in regulating cell survival, insulin signaling, angiogenesis and tumor formation as well as controlling apoptosis. Importantly, the signaling pathway involving AKT1 kinase appears to be essential for the normal development and function of the nervous system. Dysregulation of Akt1 contributes to a number of serious diseases, including cancer, diabetes, cardiovascular and neurological diseases. 产品介绍 The AKT1 Assay Kit is designed to measure AKT1 activity for screening and profiling applications using Kinase-Glo® Kinase Assay as a detection reagent.
询价背景介绍 TAK1 is a serine/threonine protein kinase that mediates signaling by TGFβ and morphogenetic protein (BMP). In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (NF-κB). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. It has been implicated in various inflammation disorders and cancers, including breast and pancreatic cancer. 产品介绍 The TAK1-TAB1 Kinase Assay Kit is designed to measure TAK1-TAB1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价背景介绍 MAPK-interacting serine/threonine-protein kinase 1 (MNK1) is a member of the serine/threonine family that plays a role in mitotic cell cycle progression. Alteration of MNK1 has been shown in various cancers such as breast carcinoma and melanoma. MNK1 phosphorylates eukaryotic translation initiation factor 4E (eIF4E), enhancing phosphorylation of quiescent cells and rendering eIF4E oncogenic. 产品介绍 The MNK1 Kinase Assay Kit is designed to measure MNK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价产品介绍 Coronavirus disease 2019 (COVID-19) increases the risk of developing Acute Respiratory Distress Syndrome (ARDS), which is often fatal at the late stages of the infection when the SAR-CoV-2 virus causes significant damage to the lungs. As a first step of the viral replication strategy, the virus attaches to the host cell surface before entering the cell. The Spike protein receptor binding domain (RBD) recognizes and attaches to the Angiotensin-Converting Enzyme 2 (ACE2) receptor found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. Drugs targeting the interaction between the Spike protein of SARS-CoV-2 and ACE2 may offer some protection against the viral infection. The ACE2:SARS-CoV-2 Spike (RBD) Inhibitor Screening Colorimetric Assay Kit is designed for screening and profiling inhibitors of this interaction. The key to this kit is the high sensitivity of detection of Fc-tagged Spike protein by HRP-labeled Anti-mouse-Fc. Only a few simple steps on a microtiter plate are required for the assay. First, ACE2 protein is attached to a clear nickel-coated 96-well plate. Next, SARS-CoV-2 Spike-Fc is incubated with ACE2 on the plate. Finally, the plate is treated with HRP-labeled anti-Fc, followed by addition of an HRP substrate to produce color, which can then be measured using a UV/Vis spectrophotometer microplate reader.
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Interleukin 6 (IL-6), and its receptor complex interleukin 6 receptor (IL-6R, CD126)-gp130 (CD130), play an important role in immune response. Elevated IL-6 leads to an acute severe systemic inflammatory response known as 'cytokine storm', where an uncontrolled and excessive release of pro-inflammatory cytokines can cause multisystem organ failure and death. Mortality in COVID-19 patients has been linked to this severe response induced by the virus. Tocilizumab is a humanized monoclonal antibody against the IL-6R used as immunosuppressive drug, and it is emerging as an alternative treatment for COVID-19 patients at risk for 'cytokine storm'.
The IL-6:IL-6R Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of this receptor-ligand interaction. The key to this kit is the high sensitivity of detection of IL-6-Biotin protein by Streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, IL-6R protein is attached to a nickel-coated 96-well plate. Next, IL-6-Biotin incubated with IL-6R on the plate. Finally, the plate is treated with Streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which then can be measured using a chemiluminescence reader.
背景介绍 SPHK1 is a lipid enzyme that catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP). It has been implicated in tumor progression through cell proliferation and motility. High levels of SPHK1 have been associated with increased mortality in various forms of human cancer. 产品介绍 The SPHK1 Assay Kit is designed to measure SPHK1 activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 A20 or TNFAIP3 is a protein that is integral to controlling NF-kB activation. It was first identified in human umbilical vein endothelial cells, but has now been induced in other cell types. A20 has been implicated in rheumatoid arthritis and other autoinflammatory and autoimmune diseases. It also plays a role in cytokine-induced signaling pathways. 产品介绍 The A20 Fluorogenic Assay Kit is designed to measure A20 activity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
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