服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
产品介绍 B-Raf substrate suitable for use with BPS Biosciences' B-Raf Kinase Assay Kits.
询价产品介绍 Bruton's tyrosine kinase or BTK, is an enzyme that plays a role in the functionality and maturation of B cells. The BTK pathway has implications for a number of autoimmune disorders including isolated growth hormone deficiency type III and rheumatoid arthritis. The BTK Assay Kit is designed to measure BTK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The BTK Assay Kit comes in a convenient 96-well format, with enough purified recombinant BTK enzyme, PolyGluTyr peptide, ATP, and kinase assay buffer for 100 enzyme reactions.
询价产品介绍 RET is a receptor kinase for GDNF (glial cell-line derived neurotrophic factor) family ligands (GFLs). Activation of wild-type RET is important in several cancers where it contributes to tumor progression through various mechanisms. In addition, it has been shown that activating mutation as well as RET rearrangement that leads constitutively active protein plays a significant role in various cancer types. Importantly, small molecule inhibitors of RET have been clinically proved as a promising therapeutic reagent in medullary thyroid cancer and are being evaluated for other types of cancers related to RET overexpression or mutation. The RET Assay Kit is designed to measure RET activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The RET Assay Kit comes in a convenient 96-well format, with enough purified recombinant RET enzyme, RET substrate peptide (IRF-1Rtide), ATP and kinase assay buffer for 100 enzyme reactions.
询价背景介绍 RIPK1 is a member of the receptor-interacting protein kinase (RIP) family. It plays an important role in cell survival as well as cell death including apoptosis and necroptosis. RIPK1 is highly expressed in Alzheimer's disease (AD) brains. Importantly, it was shown that inhibition of RIPK1 results in decrease of amyloid and inflammation levels as well as accelerating amyloid beta peptide (Aβ) degradation by microglia in vitro. 产品介绍 The RIPK1 Kinase Assay Kit is designed to measure RIPK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent.
询价背景介绍 c-Met, also known as HGFR (hepatocyte growth factor receptor), is a receptor protein tyrosine kinase encoded by the gene MET. Upon binding its ligand HGF (hepatocyte growth factor), c-Met activates multiple cellular processes including proliferation, adhesion and angiogenesis. Importantly, many studies report that c-Met is overexpressed in various carcinomas, suggesting that targeting HGF/c-Met signaling could be a promising target for cancer treatment. 产品介绍 The c-Met Kinase Assay Kit is designed to measure c-Met kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE4 selective inhibitors are currently in clinical trials for the treatment of diseases related to inflammatory disorders. PDE4B1 isoform expression predominates in cortex, however lower expression of PDE4B1 has been observed in the cerebella of subjects with autism when compared with matched controls. The PDE4B1 Assay Kit is designed for identification of inhibitors of PDE4B1 using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE4B1 to the binding agent. Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearly-polarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light. The PDE4B1 Assay Kit comes in a convenient 96-well format, with purified PDE4B1 enzyme, fluorescently labeled PDE4B1 substrate (cAMP), binding agent, and PDE assay buffer for 100 enzyme reactions. The key to the PDE4B1 Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for PDE4B1 reactions. First, the fluorescently labeled cAMP is incubated with a sample containing PDE4B1 for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.
询价产品介绍 This Blocking Buffer 1 is optimized for minimizing background in various BPS Bioscience assay kits. The BPS Bioscience Blocking Buffer improves S/B ratio of HMTs NSD2 and SetDB2 ELISAs with respect to competitor blocking buffer by both decreasing background (0% Activity control, no enzyme) and increasing assay signal (100% Activity control, enzyme without inhibitor).
询价背景介绍 ALK1, also known as activin receptor-like kinase 1 (ACVRL1) is a type I receptor from the TGF-β family of transmembrane serine/threonine kinases. Mutation of ALK1 is seen to play a role in pulmonary arterial hypertension (PAH), Osler-Weber-Rendu syndrome, and vascular smooth muscle cell development. 产品介绍 The ALK1 Kinase Assay Kit is designed to measure ALK1 kinase activity for screening and profiling applications using ADP-Glo® Kinase Assay as a detection reagent. The ALK1 Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant ALK1 enzyme, ALK1 substrate, ATP and kinase assay buffer for 100 enzyme reactions.
询价产品介绍 The tropomyosin receptor kinases (TRK) are a family of tyrosine receptor kinases, which include TrkA, TrkB and TrkC. TrkA is activated by binding to nerve growth factor (NGF), resulting in activation of cell proliferation through the RAS/MAPK/ERK and PLCγ/PI3K pathways. Constitutive activation of TrkA is associated with colorectal cancer, suggesting TrkA inhibitors may have potential therapeutic value. The TrkA Assay Kit is designed to measure TrkA activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The TrkA Assay Kit comes in a convenient 96-well format, with enough purified recombinant TrkA enzyme, TrkA substrate, ATP and kinase assay buffer for 100 enzyme reactions.
询价
