服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with C797S mutation. Genbank Accession NM_005228, a.a. 668-end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 100 kDa.
询价背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with C775S, T790M, and L858R mutations. Genbank Accession NM_005228, a.a. 668-end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 100 kDa.
询价背景介绍 EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival (1). Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms (2). Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation. 产品介绍 Recombinant Human EGFR also known as ERBB, mENA, ERBB1, and HER1 with FHEA insertion between A763 and Y764. Genbank Accession NM_005228, a.a. 695-end, with an N-terminal GST-tag, expressed in Sf9 cells via a baculovirus expression system. MW = 98 kDa.
询价背景介绍 KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2). 产品介绍 Full-length recombinant Human KAT5 (TIP60) protein also known as cPLA2 ESA1 HTATIP, HTATIP1, PLIP, and TIP. Genbank Accession NM_006388, with an N-terminal GST tag expressed by baculovirus in Sf9 insect cells. MW = 88kDa.
询价背景介绍 UBE2O or ubiquitin-conjugating enzyme E2O is a part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin. HIV-1 Tat has been identified to have a physical interaction with ubiquitin-conjugating enzyme E2O (UBE2O) in human HEK293 and Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses (1). 产品介绍 Recombinant full-length human UBE2O, also known as E2-230K, FLJ12878, and KIAA1734. Genbank Accession BC022237 with an N-terminal GST tag, expressed in Sf9 cells via a baculovirus expression system. MW = 90kDa.
询价背景介绍 UBE2K also known as UBC1 or ubiquitin-conjugating enzyme E2K belongs to the ubiquitin-conjugating enzyme family which interacts with RING finger proteins. UBE2K can ubiquitinate huntingtin, the gene product for Huntington's disease. Huntingtin is ubiquitinated in peripheral cells, suggesting a role for UBE2K in the degradation of huntingtin (1). UBE2K plays a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases (2). UBE2K also plays a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. 产品介绍 Recombinant full length UBE2K (UBC1) protein also known as E2-25K, HIP2, HYPG, LIG, and UB1. Genbank Accession NM_005339, with an N-terminal His-tag, expressed in E. coli cells. MW = 25kDa.
询价背景介绍 UBE2G1 (UBC7) or ubiquitin-conjugating enzyme E2G 1 is a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins which are involved in degradation of muscle-specific proteins. UBC7 is highly expressed in skeletal muscle (1). UBC7 is involved in the selective ubiquitylation of different substrates by the same E3 complex (2). 产品介绍 Recombinant full length Human UBE2G1, also known as UBC7, E217K, and UBE2G. Genbank Accession NM_003342, N-terminal His-tag, expressed in E. coli cells. MW = 21kDa.
询价背景介绍 UBE2E3 also known as UBCH9 or ubiquitin-conjugating enzyme E2E 3 is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination, the covalent attachment of the protein ubiquitin (Ub) to other cellular proteins is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation that involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s(1). UBE2E3 is highly expressed in skeletal muscle (2). UBE2E3 is essential for the proliferation of RPE-1 cells and is downregulated during RPE layer maturation in the developing mouse eye. These findings indicate that UBE2E3 is a major enzyme in modulating the balance between RPE cell proliferation and differentiation. 产品介绍 Recombinant full length human UBE2E3, also known as UBCH9 and UbcM2. Genbank Accession NM_006357, with an N-terminal His-tag, expressed in E. coli cells. MW = 25kDa.
询价背景介绍 UBE2D2(UBC4) Protein or ubiquitin-conjugating enzyme E2D2 is a member of the E2 ubiquitin-conjugating enzyme family which functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. UBE2D2 specifically ubiquitinates E6AP and in vivo inhibition of UBE2D2 can lead to inhibition of E6-stimulated p53 degradation (1). UBE2D2 could conjugate ubiquitin to target proteins in an E6AP-dependent manner. 产品介绍 Recombinant full-length Xenopus UBE2D2, also known as UBC4, PUBC1, UBC4/5, UBCH5B, and E2(17)KB2. Genbank Accession No. NM_001093036, with an N-terminal His-tag, expressed in E. coli. MW=17 kDa.
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