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背景介绍 LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. LATS2 interacts with a negative regulator of p53 and function in a positive feedback loop with p53 that responds to cytoskeleton damage and this interaction provokes centrosome/mitotic apparatus dysfunction (1). LATS2 plays an essential role in the maintenance of mitotic fidelity and genomic integrity (2). 产品介绍 Human LATS2 protein with N-terminal GST-Tag, GenBank Accession No. NM_014572, a.a 480-1088, expressed in an Sf9 expression system. MW = 110 kDa.
询价背景介绍 14-3-3 zeta (also known as tyrosine 3-monooxygenase /tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2). 产品介绍 Mouse 14-3-3 zeta Protein, GenBank Accession No. NM_011740, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 31 kDa.
询价背景介绍 14-3-3 zeta (also known as tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 zeta protein plays a key role in cancer biology by being an important regulator of major cellular processes such as proliferation, differentiation, senescence and apoptosis (1). 14-3-3 zeta protein has been shown to interact with the IRS1 protein, suggesting a role for this protein in regulating insulin sensitivity by interrupting the association between the insulin receptor and IRS1 (2). 产品介绍 Human 14-3-3 zeta Protein, GenBank Accession No. NM_012479, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 31 kDa.
询价背景介绍 14-3-3 theta (also known as tyrosine 3-monooxygenase /tryptophan 5-monooxygenase activation protein, theta polypeptide) is a member of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Through interaction with ASK1, c-jun NH-terminal kinase, and p38 mitogen-activated protein kinase (MAPK), 14-3-3 theta plays an important role in controlling apotopsis (1). Induced expression of 14-3-3 theta protein has been reported in patients with amyotrophic lateral sclerosis. Additionally, 14-3-3 theta has been observed to mediate nucleo-cytoplasmic shuttling of the N protein (coronavirus nucleocapsid protein) which causes severe acute respiratory syndrome (2). 产品介绍 Human 14-3-3 theta Protein, GenBank Accession No. NM_006826, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 30 kDa.
询价背景介绍 14-3-3 sigma or stratifin is a protein that is strongly induced by gamma irradiation and other DNA-damaging agents (1). The induction of 14-3-3 sigma is mediated by a p53 responsive element. Exogenous introduction of 14-3-3 sigma into cycling cells results in a G2 cell cycle arrest (2). Knockout of 14-3-3 sigma in cells showed that the cells are unable to maintain cell cycle arrest after DNA damage. The 14-3-3sigma -/- cells die as they enter mitosis. This process is associated with a failure of the 14-3-3sigma-deficient cells to sequester the proteins that initiate mitosis and prevent them from entering the nucleus. Thus, 14-3-3 sigma plays an important role in maintaining the G2 checkpoint in cells and preventing mitotic death. 产品介绍 Human 14-3-3 sigma Protein, GenBank Accession No. NM_006142, full length, with N-terminal His-tag, expressed in Sf9 insect cells using baculovirus. MW = 30 kDa.
询价背景介绍 14-3-3 epsilon, also known as tyrosine 3-mono-oxygenase/tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. 14-3-3 epsilon has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways (1). 14-3-3epsilon interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of 14-3-3 epsilon, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions (2). 产品介绍 Mouse 14-3-3 epsilon Protein, GenBank Accession No. NM_009536, full length, with N-terminal His tag, expressed in Sf9 insect cells using baculovirus. MW = 33 kDa.
询价背景介绍 14-3-3 epsilon also known as tyrosine 3-mono-oxygenase/tryptophan 5-monooxygenase activation protein is a member of the 14-3-3 family. 14-3-3 epsilon has been reported to be involved in heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK) pathways (1). 14-3-3 epsilon interaction with the deubiquitinating enzyme UBPY, also known as USP8, regulates cargo sorting and membrane traffic at early endosomes. Association of 14-3-3 epsilon, HSF1 with ERK during heat shock may modulate the amplitude of the response and control the termination of HSP expression on resumption of growth conditions (2). 产品介绍 Human 14-3-3 epsilon Protein, GenBank Accession No. NM_006761, full length, with N-terminal His tag, expressed in Sf9 insect cells using baculovirus. MW = 30 kDa.
询价背景介绍 14-3-3 alpha/beta is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins (1). 14-3-3 alpha/beta protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. 14-3-3-alpha/beta interacts with the TSC1-TSC2 dimer (2). The interaction required phosphorylation of TSC2 at Ser1210. Binding of 14-3-3-alpha/beta to TSC2 did not alter the interaction between TSC1 and TSC2, but it reduced the ability of the complex to inhibit phosphorylation of ribosomal protein S6 kinase impairing the ability of the complex to inhibit cell growth. 产品介绍 Mouse 14-3-3 alpha/beta Protein, GenBank Accession No. NM_018753, full length, with N-terminal His tag, expressed in Sf9 insect cells using baculovirus. MW = 32 kDa.
询价背景介绍 14-3-3 alpha/beta is a member of the highly conserved 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins (1). 14-3-3 alpha/beta protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. 14-3-3-alpha/beta interacts with the TSC1-TSC2 dimer (2). The interaction required phosphorylation of TSC2 at Ser1210. Binding of 14-3-3-alpha/beta to TSC2 did not alter the interaction between TSC1 and TSC2, but it reduced the ability of the complex to inhibit phosphorylation of ribosomal protein S6 kinase impairing the ability of the complex to inhibit cell growth. 产品介绍 Human 14-3-3 alpha/beta Protein, GenBank Accession No. NM_003404, full length, with C-terminal His tag, expressed in an E. coli expression system. MW = 32 kDa.
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