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背景介绍 CD20 (MS4A1) is a glycosylated phosphoprotein expressed on the cell surface of B cells. Although the functional significance of CD20 is not clear, and CD20 has no known ligands, CD20 has been shown to regulate intracellular calcium levels. CD20 is a highly attractive target antigen for immunotherapy because it is expressed on more than 90% of patients with B-cell lymphoma. First approved in 1997, Rituximab (Rituxan) is a chimeric monoclonal antibody targeting CD20 and has been classified by the World Health Organization as an “Essential Medicine”. Since then, additional monoclonal antibodies against CD20 have been approved or are being tested in clinical trials for the treatment of multiple sclerosis (MS), chronic lymphocytic leukemia (CLL), follicular lymphoma, diffuse large B cell lymphoma (DLBCL), rheumatoid arthritis, non-Hodgkin’s lymphoma, systemic lupus erythematosus, and myalgic encephalomyelitis (chronic fatigue syndrome). Additionally, more recently, anti-CD20-CD19 bispecific CAR-T cells have been developed to address concerns over potential relapse. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human CD20 protein, also known as MS4A1 (Genbank #NM_152866). Surface expression of CD20 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD20 expression (High, Medium) to mimic different stages of cancer target cells with various CD20 expression levels.
询价背景介绍 CD38 (cyclic ADP-ribose hydrolase 1, ADPRC1) is a glycoprotein and ectoenzyme which plays an important role in regulating intracellular calcium. CD38 is a highly attractive target antigen for immunotherapy because it is highly expressed on multiple myeloma cells, and at relatively low levels on normal lymphoid and myeloid cells. Expression of CD38 has also been associated with HIV infection, leukemia, and type II diabetes mellitus. CD38 CAR-T is a T cell product engineered by retroviral transduction to express a fully human CD38-specific CAR (chimeric antigen receptor). In 2015, the FDA approved daratumumab (Darzalex), a breakthrough therapy drug targeting CD38, for the treatment of multiple myeloma. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human CD20 protein, also known as MS4A1 (Genbank #NM_152866). Surface expression of CD20 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD20 expression (High, Medium) to mimic different stages of cancer target cells with various CD20 expression levels.
询价背景介绍 CD38 (cyclic ADP-ribose hydrolase 1, ADPRC1) is a glycoprotein and ectoenzyme which plays an important role in regulating intracellular calcium. CD38 is a highly attractive target antigen for immunotherapy because it is highly expressed on multiple myeloma cells, and at relatively low levels on normal lymphoid and myeloid cells. Expression of CD38 has also been associated with HIV infection, leukemia, and type II diabetes mellitus. CD38 CAR-T is a T cell product engineered by retroviral transduction to express a fully human CD38-specific CAR (chimeric antigen receptor). In 2015, the FDA approved daratumumab (Darzalex), a breakthrough therapy drug targeting CD38, for the treatment of multiple myeloma. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human CD20 protein, also known as MS4A1 (Genbank #NM_152866). Surface expression of CD20 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD20 expression (High, Medium) to mimic different stages of cancer target cells with various CD20 expression levels.
询价背景介绍 CD38 (cyclic ADP-ribose hydrolase 1, ADPRC1) is a glycoprotein and ectoenzyme which plays an important role in regulating intracellular calcium. CD38 is a highly attractive target antigen for immunotherapy because it is highly expressed on multiple myeloma cells, and at relatively low levels on normal lymphoid and myeloid cells. Expression of CD38 has also been associated with HIV infection, leukemia, and type II diabetes mellitus. CD38 CAR-T is a T cell product engineered by retroviral transduction to express a fully human CD38-specific CAR (chimeric antigen receptor). In 2015, the FDA approved daratumumab (Darzalex), a breakthrough therapy drug targeting CD38, for the treatment of multiple myeloma. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human CD20 protein, also known as MS4A1 (Genbank #NM_152866). Surface expression of CD20 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD20 expression (High, Medium) to mimic different stages of cancer target cells with various CD20 expression levels.
询价背景介绍 Receptor tyrosine-protein kinase erbB-2 (HER2 or CD340) is a protein that in humans is encoded by the ERBB2 gene. Over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. HER2 over-expression is also known to occur in ovarian, stomach, adenocarcinoma of the lung, aggressive forms of uterine cancer and gastric cancer. Signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ERBB2 protein (Genbank NM_004448.2). Surface expression of ERBB2 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ERBB2 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ERBB2 expression levels.
询价背景介绍 Receptor tyrosine-protein kinase erbB-2 (HER2 or CD340) is a protein that in humans is encoded by the ERBB2 gene. Over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. HER2 over-expression is also known to occur in ovarian, stomach, adenocarcinoma of the lung, aggressive forms of uterine cancer and gastric cancer. Signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ERBB2 protein (Genbank NM_004448.2). Surface expression of ERBB2 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ERBB2 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ERBB2 expression levels.
询价背景介绍 Receptor tyrosine-protein kinase erbB-2 (HER2 or CD340) is a protein that in humans is encoded by the ERBB2 gene. Over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. HER2 over-expression is also known to occur in ovarian, stomach, adenocarcinoma of the lung, aggressive forms of uterine cancer and gastric cancer. Signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ERBB2 protein (Genbank NM_004448.2). Surface expression of ERBB2 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ERBB2 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ERBB2 expression levels.
询价背景介绍 Tyrosine-protein kinase transmembrane receptor (ROR1) is an enzyme that in humans is encoded by the ROR1 gene. The ROR1 is expressed by tumor cells of various hematologic and solid malignancies and is largely absent from postnatal healthy cells and tissues. Treatment with a humanized monoclonal antibody specific for ROR1 (UC-961) can inhibit the capacity of ovarian cancer cells to migrate or engraft immune-deficient mice. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ROR1 protein (Genbank NM_005012.3). Surface expression of ROR1 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ROR1 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ROR1 expression levels.
询价背景介绍 Tyrosine-protein kinase transmembrane receptor (ROR1) is an enzyme that in humans is encoded by the ROR1 gene. The ROR1 is expressed by tumor cells of various hematologic and solid malignancies and is largely absent from postnatal healthy cells and tissues. Treatment with a humanized monoclonal antibody specific for ROR1 (UC-961) can inhibit the capacity of ovarian cancer cells to migrate or engraft immune-deficient mice. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ROR1 protein (Genbank NM_005012.3). Surface expression of ROR1 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ROR1 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ROR1 expression levels.
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