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产品介绍
The 3X Immuno Buffer 1 is optimized for use with a large variety of Immunotherapy Assay Kits:
• CD28:B7-1[Biotinylated] Inhibitor Screening Assay Kit
• CD28:B7-2[Biotinylated] Inhibitor Screening Assay Kit
• CD47:SIRP-α[Biotinylated] Inhibitor Screening Assay Kit
• CD47:SIRP-γ[Biotinylated] Inhibitor Screening Assay Kit
• CD137[Biotinylated]:CD137L Inhibitor Screening Assay Kit
• CD226:CD155 Homogeneous Assay Kit
• CD226:CD112 Homogeneous Assay Kit
• CTLA4:B7-1 TR-FRET Assay Kit
• CTLA4:B7-1[Biotinylated] Inhibitor Screening Assay Kit
• CTLA4[Biotinylated]:B7-2 Inhibitor Screening Assay Kit
• IL-17RA[Biotin]:IL-17A Inhibitor Screening Assay Kit
• OX40[Biotinylated]:OX40L Inhibitor Screening Assay Kit
• PD-L1:B7-1[Biotinylated] Inhibitor Screening Assay Kit
• PD-1:PD-L2[Biotinylated] Inhibitor Screening Colorimetric Assay Kit
• PD-1[Biotinylated]:PD-L1 Homogeneous Assay Kit
• PD-1[Biotinylated]:PD-L1 Inhibitor Screening Assay Kit
• PD-1[Biotinylated]:PD-L1 Inhibitor Screening Colorimetric Assay Kit
• PD-1[Biotinylated]:PD-L2 Inhibitor Screening Assay Kit
• PD-1[Biotinylated]:PD-L2 Inhibitor Screening Colorimetric Assay Kit
• TIGIT:CD112 Homogeneous Assay Kit
背景介绍 Fibroblast activation protein alpha (FAP-alpha) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family and is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP expression under physiological conditions is scarce in healthy adult tissues. But FAP gene is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has also been proposed as a molecular target of cancer therapies, and a great deal of research has gone into design and testing of diverse FAP-targeted treatments. 产品介绍 Recombinant FAP-CHO K1 cell line stably expressing a full length human FAP-alpha protein (Genbank accession No: NM004460.2). Surface expression of FAP was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of FAP expression (High, Medium, or Low) to mimic different stages of cancer target cells with various FAP expression levels.
询价背景介绍 Fibroblast activation protein alpha (FAP-alpha) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family and is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP expression under physiological conditions is scarce in healthy adult tissues. But FAP gene is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has also been proposed as a molecular target of cancer therapies, and a great deal of research has gone into design and testing of diverse FAP-targeted treatments. 产品介绍 Recombinant FAP-CHO K1 cell line stably expressing a full length human FAP-alpha protein (Genbank accession No: NM004460.2). Surface expression of FAP was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of FAP expression (High, Medium, or Low) to mimic different stages of cancer target cells with various FAP expression levels.
询价背景介绍 Fibroblast activation protein alpha (FAP-alpha) belongs to the dipeptidyl peptidase IV (DPP4; CD26) gene family and is a cell-surface serine protease that acts on various hormones and extracellular matrix components. FAP expression under physiological conditions is scarce in healthy adult tissues. But FAP gene is highly upregulated in a wide variety of cancers, and is often used as a marker for pro-tumorigenic stroma. It has also been proposed as a molecular target of cancer therapies, and a great deal of research has gone into design and testing of diverse FAP-targeted treatments. 产品介绍 Recombinant FAP-CHO K1 cell line stably expressing a full length human FAP-alpha protein (Genbank accession No: NM004460.2). Surface expression of FAP was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of FAP expression (High, Medium, or Low) to mimic different stages of cancer target cells with various FAP expression levels.
询价背景介绍 CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage that belongs to the sialic acid-binding immunoglobulin (Ig)-like family. CD33 can be stimulated by sialic acid residues on glycoproteins or glycolipids, resulting in a signaling cascade that inhibits phagocytosis in cells and suppresses immune cell proliferation. CD33 overexpression is one of top-ranked Alzheimer's disease risk factors and CD33 is the target of gemtuzumab ozogamicin, an antibody-drug for the treatment of patients with acute myeloid leukemia. 产品介绍 Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.
询价背景介绍 CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage that belongs to the sialic acid-binding immunoglobulin (Ig)-like family. CD33 can be stimulated by sialic acid residues on glycoproteins or glycolipids, resulting in a signaling cascade that inhibits phagocytosis in cells and suppresses immune cell proliferation. CD33 overexpression is one of top-ranked Alzheimer's disease risk factors and CD33 is the target of gemtuzumab ozogamicin, an antibody-drug for the treatment of patients with acute myeloid leukemia. 产品介绍 Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.
询价背景介绍 CD33 or Siglec-3 is a transmembrane receptor expressed on cells of myeloid lineage that belongs to the sialic acid-binding immunoglobulin (Ig)-like family. CD33 can be stimulated by sialic acid residues on glycoproteins or glycolipids, resulting in a signaling cascade that inhibits phagocytosis in cells and suppresses immune cell proliferation. CD33 overexpression is one of top-ranked Alzheimer's disease risk factors and CD33 is the target of gemtuzumab ozogamicin, an antibody-drug for the treatment of patients with acute myeloid leukemia. 产品介绍 Recombinant CD33 -CHO K1 cell line stably expressing the full length human C33/Siglec-3 receptor (GenBank Accession: BC028152.1). Surface expression of CD33 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of CD33 expression (High, Medium, Low) to mimic different stages of cancer target cells with various CD33 expression levels.
询价背景介绍 BAFF Receptor (B-cell activating factor receptor, BAFF-R) is an essential factor for B cell maturation and survival. In humans it is encoded by the TNFRSF13C gene. BAFF-R function is impressively documented in humans by a homozygous deletion, which leads to an almost complete block of B cell development at the stage of immature/transitional B cells. The resulting immunodeficiency is characterized by B-lymphopenia, agammaglobulinemia, and impaired humoral immune responses. 产品介绍 Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.
询价背景介绍 BAFF Receptor (B-cell activating factor receptor, BAFF-R) is an essential factor for B cell maturation and survival. In humans it is encoded by the TNFRSF13C gene. BAFF-R function is impressively documented in humans by a homozygous deletion, which leads to an almost complete block of B cell development at the stage of immature/transitional B cells. The resulting immunodeficiency is characterized by B-lymphopenia, agammaglobulinemia, and impaired humoral immune responses. 产品介绍 Recombinant human BAFF-R-CHO K1 cell line stably expressing full length human BAFF-R/TNFRSF13C receptor (GenBank Accession: NM_052945.3). Surface expression of BAFF-R was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of BAFF-R expression (High, Medium, Low) to mimic different stages of cancer target cells with various BAFF-R expression levels.
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