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产品介绍 Human MEK1 (K97R) (GenBank Accession No. NM_002755), full length with lysine97 to arginine mutation and C-terminal His-tag, MW=44.3 kDa, expressed in E. coli. The K97R mutation prevents ATP binding, making the kinase inactive.
询价产品介绍 Human recombinant LOK1, also known as STK10 (GenBank Accession No. NM_005990), a.a. 1-348 with N-terminal His-tag, expressed in a Baculovirus infected Sf9 cell expression system. MW = 43.2 kDa.
询价背景介绍 p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. 产品介绍 Recombinant full-length human p38alpha was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_139012.
询价产品介绍 Complex of human LKB1, also known as STK11 (GenBank Accession No. NM_000455, a.a. 2-433, with N-terminal His-tag), MO25 (GenBank Accession No. NM_016289, a.a. 2-341, with N-terminal GST-tag), and STRAD (GenBank Accession No. NM_001003787, a.a. 2-431, with N-terminal GST-tag). Calculated MW=49 kDa* (LKB1), 66 kDa (MO25), and 74 kDa (STRAD), expressed in Sf9 cells using a Baculovirus expression system. *LKB1 runs anomalously on SDS-PAGE.
询价产品介绍 Human BRAF (b-RAF) 9GenBank Accession #NM_004333), a.a. 417-766 (end) with N-terminal GST-tag, MW = 66 kDa, expressed in Sf9 cells using a Baculovirus expression system.
询价产品介绍 Human IRAK4 (GenBank Accession No. NM_001114182), a.a. 2-end with N-terminal GST-tag, MW= 77.5 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
询价背景介绍 p70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1). 产品介绍 Human p70S6Kb1, also known as ribosomal protein S6 kinase, 70 kDa, polypeptide 1 (RPS6KB1), GenBank Accession No. NM_003161, amino acid 1-421 with N-terminal GST tag, MW=74 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
询价产品介绍 Human/Mouse ERK2/MAPK2 (K52R) (GenBank Accession No. NM_0011949), full length with mutation on lysine52 to arginine and with an N-terminal His-tag, MW=42 kDa, expressed in E. coli . The K52R mutation prevents ATP binding, making the kinase inactive.
询价产品介绍 Human DYRK2 (GenBank Accession No. NM_003583), full length with N-terminal His-tag, MW = 63.5 kDa, expressed in Baculovirus infected Sf9 cell expression system.
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