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产品介绍 The HSP90β (C-terminal) Inhibitor Screening Assay Kit is designed to measure the inhibition of HSP90β binding to its protein target PPID (also known as Cyclophilin D). With this kit, only three simple steps on a microtiter plate are required. First, a sample containing HSP90β, PPID, and an inhibitor of choice is incubated for thirty minutes. Next, acceptor beads are added, then donor beads, followed by reading the Alpha-counts.
询价产品介绍 Human Heat Shock Protein 90 beta (HSP90β), GenBank Accession No. NM_001271969, a.a. 527-724 (end) with N-terminal His-tag and N-terminal Avi-tag™, MW = 25 kDa, expressed in an E. coli expression system and enzymatically biotin-labeled using Avi-tag™ technology.
询价产品介绍 A novel geldanamycin fluorescent probe optimized for use with BPS's HSP90 Assay Kits. May also be used for detection of cell surface HSP90.
询价产品介绍
Concentrated aqueous buffer optimized for use with the following BPS Bioscience HSP90 assay kits:
• HSP90α Assay Kit (96 well) #50293 96 reactions
• HSP90α Assay Kit (384 well) #50298 384 reactions
• HSP90β Assay Kit (96 well) #50294 96 reactions
• HSP90β Assay Kit (384 well) #50299 384 reactions
Note: This buffer is not designed for use with the HSP90β (C-Terminal) Inhibitor Screening Assay Kit, Cat. # 50314.
产品介绍 Human MTAP (methylthioadenosine phosphorylase), GenBank Accession No. NM_002451, a.a. 2-end, with N-terminal GST-tag, MW=57 kDa, expressed in an E. coli expression system.
询价背景介绍 PLK3 or Polo-like kinase 3 is a cytokine-inducible kinase that is a member of the Polo family of serine/threonine protein kinases. PLK3 contains both a catalytic domain and a putative regulatory domain and plays an important role in the regulation of cell cycle progression and tumorigenesis. PLK3 is closely associated with centrosomes in several human cell lines and its localization is dependent on the integrity of microtubules. Hence, PLK3 is also involved in regulating microtubule dynamics and centrosomal function. 产品介绍 Human N-terminal MBP tagged Plk3 polo box domain (GenBank Accession No.NM_004073/NP_004064), a.a. 335-646 with C-terminal His-tag, MW=80.5 kDa, expressed in an E. coli expression system.
询价背景介绍 PLK1 is a member of the Polo-Like Kinase family that localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics. PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death. 产品介绍 Human Plk1 polo box domain (GenBank Accession No. NM_005030), a.a. 367-end with N-terminal GST-tag, MW=53 kDa, expressed in an E. coli expression system.
询价产品介绍 Human sphingosine-1-phosphate lyase 1 (GenBank Accession No. NM_003901), a.a. 59-end, with C-terminal His-tag, MW = 57.5 kDa, expressed in a Baculovirus-infected Sf9 cell expression system.
询价背景介绍 Hsp90β is a molecular chaperone with essential functions in maintaining transformation. Inhibition of Hsp90β functions has been shown to play a role in tumorigenesis and disease progression. 产品介绍 The HSP90β (N-terminal) Assay Kit is designed for identification of HSP90β inhibitors using fluorescence polarization. The assay is based on the competition of fluorescently labeled geldanamycin for binding to purified recombinant HSP90β. The key to the HSP90β Assay Kit is the fluorescently labeled geldanamycin. Using this kit, only one simple step on a microtiter plate is required for HSP90β reactions. The fluorescently labeled geldanamycin is incubated with a sample containing HSP90β enzyme to produce a change in fluorescent polarization that can then be measured using a fluorescence reader.
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