DPY30, His-tag

背景介绍 As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. 产品介绍 Human dpy-30 homolog, or DPY30, GenBank Accession No. NM_032574, a.a. 2 - 99 (end) with N-terminal His-tag, MW= 12 kDa, expressed in an E. coli expression system.

RbBP5, His-tag

背景介绍 RbBP5 binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. In embryonic stem (ES) cells, RbBP5 plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3Lys4 methylation at key developmental loci, including that mediated by retinoic acid. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at Lys4 of histone H3. 产品介绍 Human retinoblastoma binding protein 5 (RbBP5), GenBank Accession No. NM_005057, a.a. 2 - 538 (end) with N-terminal His-tag, MW= 60 kDa, expressed in an E. coli expression system.

Ash2L, His-tag

WDR5, His-tag

背景介绍 As part of the MLL1/MLL complex, WDR5 is involved in methylation and dimethylation at Lys4 of histone H3, which is a specific tag for epigenetic transcriptional activation. As part of the NSL complex, it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. WDR5 may regulate osteoblasts differentiation. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes WDR5 contains 7 WD repeats. 产品介绍 Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3, GenBank Accession No. NM_017588, a.a. 2-334(end), with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

PFKFB4, His-tag

产品介绍 Human recombinant 6- phosphofructo-2-kinase/fructose-2,6- bisphosphatase 4 (PFKFB4), also known as 6PF-2-K/Fru-2,6-P2ase 4, and PFK/FBpase 4, a.a. 2-469 with an Nterminal His-tag, GenBank Accession No. NM_004567/NM_004558, MW = 55 kDa, expressed in an E. coli cell expression system.

PD-1, FLAG-Avi-His-tag (Human)

产品介绍 Human secreted programmed cell death 1 (PD-1), also known as PDCD1, SLEB2, CD279 and HPD-L, GenBank Accession No. NM_005018, a.a. 25-167, with C-terminal FLAG-Avi-His-tags, MW=20 kDa, expressed in a HEK293 cell expression system. This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

CD112, His-tag

产品介绍 Human secreted CD112, also known as Nectin-2, Herpes virus entry mediator B, HVEB, PVRL2, and PRR2, GenBank Accession No. NM_002856, a.a. 32-360 with a C-terminal His-tag, expressed in a HEK293 cell expression system. MW = 36.4 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation.

Mouse IDO1, His-tag

产品介绍 Mouse IDO1, also known as Indoleamine 2,3-dioxygenase 1, GenBank Accession No. NM_008324, a.a. 2-407(end) with an Nterminal His-tag, expressed in the presence of hemin in an E. coli cell expression system. MW = 46 kDa.

TDO, His-tag (Human)

产品介绍 Human Tryptophan 2,3-dioxygenase (TDO), also known as TDO2, GenBank Accession No. NM_005651, a.a. 2-406(end) with an N-terminal His-tag, expressed in an E. coli cell expression system. MW = 49 kDa.