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背景介绍 The CD7 antigen is a single-domain immunoglobulin superfamily molecule. It plays an essential role in T-cell interactions and T-cell/B-cell interaction during early lymphoid development. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Interestingly, loss of CD7 antigen is observed in the subset of CD4+ memory T cells in some pathological conditions. Several studies indicate that the number of CD4+ CD7– T cells increase in chronic inflammation and various T-cell malignancies. CD7 is expressed in 95% of T-cell acute lymphoblastic leukemia (T-ALL) cases, which makes it an ideal target for T-ALL treatment. 产品介绍 Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels.
询价背景介绍 The Raji line was established from a Burkitt's lymphoma patient. Raji cells constitutively express B cell antigens CD19, CD20, and CD22, and offer a physiologically relevant platform to evaluate cancer-directed immunotherapies such as Chimeric Antigen Receptor (CAR) T-cells. The Firefly Luciferase - Raji Recombinant Cell Line makes an excellent target for CAR-T or NK cells targeting CD19, CD20, or CD22. The signal generated by the firefly luciferase reporter is proportional to Raji cell numbers and facilitates the quantification of Raji cells killing upon co-culture with CAR-T or NK cells. 产品介绍 Recombinant Raji cells constitutively expressing firefly (Photinus pyralis) luciferase under the control of a CMV promoter.
询价背景介绍 CD43 is a heavily glycosylated type I transmembrane protein expressed on the surface of most hemopoietic cells. It is abundantly expressed on the surface of T cells and functions as a co-stimulatory molecule by transducing activation signals through its cytoplasmic domain. Ultimately, it is thought that CD43 contributes to downstream T cell gene regulation and modulates cell function. 产品介绍 Recombinant CHO cell line stably expressing full length human CD43 gene (sialophorin, gpL115, leukosialin, SPN; ref. seq. NM_003123) under the control of the CMV promoter.
询价背景介绍 CD2 (Cluster of differentiation 2, also known as T11, SRBC, or LFA-2) is a cell adhesion molecule and surface antigen found on the surface of all peripheral blood T-cells and natural killer (NK) cells. It is used as specific marker of T and NK cells. CD2 interacts with LFA3 (CD58) on antigen-presenting cells to optimize immune recognition. It also functions as a co-stimulator in T and NK cells. It is being investigated as a therapeutic target for the treatment of T cell lymphomas and leukemias. 产品介绍 Recombinant clonal CHO-K1 stable cell line constitutively expressing full length human CD2 protein. The surface expression of CD2 in this cell line was validated by flow cytometry.
询价产品介绍 Recombinant CHO-K1 cells constitutively expressing human B7-H7 (also known as HHLA2: HERV-H LTR-associating protein 2, GenBank accession #NM_007072) and an engineered T cell receptor (TCR) activator. B7-H7 mediates an immune-stimulatory signal via TMIGD2 (Transmembrane and immunoglobulin domain containing 2) in naïve T cells while it delivers an immune-inhibitory signal through KIR3DL3 in activated T cells and Natural Killer (NK) cells.
询价背景介绍 CD34 (Cluster of Differentiation-34) is a single-pass transmembrane phosphoglycoprotein and a stem cell antigen. It is a receptor for L-Selectin (CD62L) and CrkL ligands, as well as E- and P-Selectin in the bone marrow extracellular matrix. It can act both as a cell adhesion molecule and as an adhesion blocking molecule against mast cells, dendritic precursors and eosinophils. CD34 is most commonly characterized by its expression on the surface of hematopoietic stem cells (HSC), and is therefore utilized for positive selection and counting of CD34+ cells in clinical bone marrow transplants. CD34(-) HSCs have also been identified, which exhibit a distinct progenitor profile. CD34 bears a controversial identity as a mesenchymal stromal cell (MSC) marker, the evidence for which is highly context-dependent. In addition, CD34 is expressed by other progenitor cell types such as quiescent keratocytes, stem cells within the hair follicle that replace epithelial layers of the skin, and within sub-populations of interstitial cells of Cajal (ICC). More recently CD34 has been identified as a potential predictor of neoadjuvant chemotherapy efficacy in cervical cancer patients, and when found in tumor stroma, is associated with better colorectal cancer survival. 产品介绍 Recombinant clonal CHO stable cell line constitutively expressing full length human CD34 protein. The surface expression of CD34 in this cell line was validated by flow cytometry.
询价背景介绍 CD14 (Cluster of Differentiation-14) is a surface antigen expressed predominantly by monocytes & macrophages. It is considered a patterned recognition receptor (PRR), which recognizes pathogen markers. Specifically, CD14 acts as a co-receptor for lipopolysaccharides (LPS) found in the outer membrane of gram-negative bacteria. Through this interaction, CD14 supports initiation of the innate immune response during bacterial infection. CD14 has also been found to contribute toward immune responses to viral pathogens such as human respiratory syncytial virus (RSV), and may amplify the inflammatory response observed in severe cases of SARS-CoV-2 infection (COVID-19). Monoclonal antibodies against CD14 are currently undergoing clinical trial as a candidate treatment to limit severe inflammatory responses common in patients hospitalized with COVID-19 产品介绍 Recombinant clonal CHO stable cell line constitutively expressing full length human CD14 protein. The surface expression of CD14 in this cell line was validated by flow cytometry.
询价产品介绍 Recombinant human CLEC1A (C-type lectin domain family 1 member A) encompassing amino acids 74-280(end). This construct contains a His-tag (10xHis) followed by an Avi-Tag™ fused to the N-terminal end of the protein by a proprietary linker. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified.
询价产品介绍 Recombinant human CLEC1A (C-type lectin domain family 1 member A) encompassing amino acids 74-280(end). This construct contains a His-tag (10xHis) followed by an Avi-Tag™ fused to the N-terminal end of the protein by a proprietary linker. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified.
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