服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
Calcitonin gene-related peptide (CGRP) receptor is a G-protein coupled receptor with three components: calcitonin receptor-like receptor (CALCRL), receptor activity-modifying protein (RAMP1) and CGRP-receptor component protein (CRCP). RAMP1 is required for both the trafficking of the calcitonin-like receptor to the plasma membrane and the coupling of the receptor with CGRP agonist. CRCP is involved in the association between the CGRP receptor and the G protein. Upon ligand binding, the complex interacts with the G protein, the Gαs subunit dissociates from the complex and activates adenylyl cyclase, which produces cAMP. Elevation of the intracellular concentration of cAMP stimulates cAMP-dependent signaling pathways, ultimately resulting in transcription factor cAMP response element binding protein (CREB) to bind to the CRE promoter and induce gene expression. Recombinant HEK293 cell line stably expressing full-length human Calcitonin receptor-like receptor (CALCRL/CRLR/CLR; accession number: NM_005795) and containing a firefly luciferase gene under the control of multimerized cAMP response element (CRE). This cell line can be used to measure the EC50 and IC50 of CALCRL agonists and antagonists using the luciferase reporter activity.
询价产品介绍 Recombinant human JAK3 (Janus Kinase 3) encompassing amino acids 511-790 corresponding to the pseudo-kinase domain JH2. The construct contains a C-terminal His tag (6xHis). The protein was affinity purified.
询价产品介绍 Recombinant human PIP5K3 (1-phosphatidylinositol 3-phosphate 5-kinase, also known as PIKFYVE), encompassing amino acids 1400-2089(end). The construct contains an N-terminal GST-tag. The protein kinase was affinity purified and is kinase-active.
询价产品介绍 Recombinant human IL2RB (interleukin 2 receptor, beta), encompassing amino acids 27-239. This construct contains a C-terminal Avi-Tag™ followed by a FLAG-tag. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.
询价产品介绍 Recombinant human IL2RB (interleukin 2 receptor, beta), encompassing amino acids 27-239. This construct contains a C-terminal Avi-Tag™ followed by a FLAG-tag. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.
询价背景介绍 Recombinant human CD161 (also known as KLRB1, killer cell lectin like receptor B1), encompassing amino acids 67-225. The protein is fused at the N-terminus with the Fc fragment of a human IgG1 followed by an Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration. 产品介绍 Recombinant human CD161 (also known as KLRB1, killer cell lectin like receptor B1), encompassing amino acids 67-225. The protein is fused at the N-terminus with the Fc fragment of a human IgG1 followed by an Avi-Tag™. The recombinant protein was affinity purified. HiP™ indicates a high purity protein (≥90% pure) and less than 10% aggregation as measured by gel filtration.
询价产品介绍 IL2R (Interleukin-2 Receptor): comprises IL2RA (Interleukin-2 receptor subunit alpha), IL2RB (Interleukin-2 receptor subunit beta), and IL2RG (Interleukin-2 receptor subunit gamma). Recombinant human IL2RA encompassing amino acids 22-240, recombinant human IL-2RB encompassing amino acids 27-239, and recombinant human IL-2RG encompassing amino acids 23-262. Each construct contains a C-terminal Avi-Tag™ followed by a C-terminal His-tag (6xHis). The three IL2R subunits were co-expressed in HEK293 cells and were affinity purified.
询价产品介绍 IL2R (Interleukin-2 Receptor): comprises IL2RB (Interleukin-2 receptor subunit beta) and IL2RG (Interleukin-2 receptor subunit gamma). Recombinant human IL-2RB encompassing amino acids 27-239. This construct contains a C-terminal Avi-Tag™ followed by a C-terminal His-tag (6xHis). Recombinant human IL-2RG encompassing amino acids 23-262. This construct contains a C-terminal Avi-Tag™ followed by a C-terminal His-tag (6xHis). The two proteins were co-expressed in HEK293 cells and were affinity purified.
询价背景介绍 The CD7 antigen is a single-domain immunoglobulin superfamily molecule. It plays an essential role in T-cell interactions and T-cell/B-cell interaction during early lymphoid development. CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Interestingly, loss of CD7 antigen is observed in the subset of CD4+ memory T cells in some pathological conditions. Several studies indicate that the number of CD4+ CD 7– T cells increase in chronic inflammation and various T-cell malignancies. CD7 is expressed in 95% of T-cell acute lymphoblastic leukemia (T-ALL) cases, which makes it an ideal target for T-ALL treatment. 产品介绍 Recombinant CD7 CHO-K1 cell lines expressing full-length human CD7 receptor (accession number: NM_006137.6). Surface expression of human CD7 was confirmed by flow cytometry. Each stable clonal cell line was selected for high or medium levels of CD7 expression to mimic different stages of cancer target cells with various CD7 expression levels.
询价
