服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
背景介绍 PHD finger protein 8 (UniProtKB/Swiss-Prot entry Q9UPP1) is a jumonji domain containing protein. Like other members of the jumonji family, PHF8 may therefore play a role in histone demethylation. Mutations in PHF8 lead to Siderius type X-linked mental retardation (MRXSSD), a mild to borderline type of mental retardation. 产品介绍 Polyclonal antibody raised in rabbit against human PHF8 (PHD finger protein 8), using 3 different KLH-conjugated synthetic peptides.
询价背景介绍 PHC2 (UniProtKB/Swiss-Prot entry Q8IXK0) is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of lysine 119 on histone H2A, rendering chromatin heritably changed in its expressibility. 产品介绍 Polyclonal antibody raised in rabbit against mouse PHC2 (polyhomeotic homolog 2) using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein.
询价背景介绍 Protein arginine deiminases catalyse the conversion of arginine residues in proteins to citrulline. PADI4 (UniProt/Swiss-Prot entry Q9UM07) catalyses the citrullination-deimination of Arg-8 and Arg-17 from histone H3 and Arg-3 from histone H4. This prevents their methylation by CARM1 and HRMT1L2/PRMT1, thereby repressing transcription. PADI4 also citrullinates EP300/P300 at Arg-2142, which favours its interaction with NCOA2/GRIP. 产品介绍 Polyclonal antibody raised in rabbit against human PADI4 (Protein-arginine deiminase type-4), using a KLH-conjugated synthetic peptide containing a sequence from the N-terminus of the protein
询价背景介绍 MeCP2 (UniProt/Swiss-Prot entry P51608) is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism. 产品介绍 Polyclonal antibody raised in rabbit against MeCP2 (Methyl-CpG-binding domain protein 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of the protein
询价背景介绍 MBD1 (UniProt/Swiss-Prot entry Q9UIS9) is a transcriptional repressor that specifically binds to methylated CpG dinucleotides in promoter sequences. MBD1 acts by recruiting a variety of histone deacetylases (HDAC's) and chromatin remodelling factors. MBD1-dependent transcriptional repression is mediated by ATF7IP through the recruitment of factors such as the histone methyltransferase SETDB1. MBD1 probably forms a complex with SETDB1 and ATF7IP which couples DNA methylation to H3K9 trimethylation and represses transcription. 产品介绍 Polyclonal antibody raised in rabbit against human MBD1 (Methyl-CpG-binding domain protein 1), using a KLH-conjugated synthetic peptide containing a sequence from the N-terminal part of the protein.
询价背景介绍 LSD1 (lysine specific demethylase 1, UniProt/Swiss-Prot entry O60341) is a component of the histone demethylase complex that uses FAD as a prosthetic goup. LSD1 may have a dual effect on gene transcription. As it demethylates the mono- and dimethylated Lys-4 of histone H3, which are associated with transcriptional activation, LSD1 can act as a repressor of gene expression. However, LSD1 is also capable of demethylating Lys-9 of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to activation of androgen receptor target genes. LSD1 therefore mediates different processes such as embryonic development, cell differentiation and proliferation, stem and cancer cell biology. 产品介绍 Polyclonal antibody raised in rabbit against human LSD1 (Lysine-specific demethylase 1), using a KLH-conjugated synthetic peptide from the inner part of the protein
询价背景介绍 KDM4D (UniProtKB/Swiss-Prot entry Q9H3R0), also known as JMJD2D, is a histone demethylase that specifically demethylates Lys-9 of histone H3, thereby playing a central role in histone code. KDM4C does not demethylate histone H3K4, H3K27, H3K36 nor H4K20. It demethylates both di- and trimethylated H3K9, while it has no activity on monomethylated residues. 产品介绍 Polyclonal antibody raised in rabbit against human JMJD2D, also known as KDM4D (lysine (K)-specific demethylase 4D), using two KLH-conjugated synthetic peptides containing a sequence from the central region of the protein
询价背景介绍 KDM1B (UniProtKB/Swiss-Prot entry Q8NB78), also known as LSD2, is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. 产品介绍 Polyclonal antibody raised in rabbit against human KDM1B (lysine (K)-specific demethylase 1B) using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively.
询价背景介绍 JMJD2b (UniProtKB/Swiss-Prot entry O94953), belongs to the JMJD2 family of histone demethylases which play an important role in the establishment of the histone code. JMJD2b specifically demethylates the trimethylated K9 of histone H3. It is not able to demethylate K4, K27 and K36 of histone H3, nor K20 of histone H4. 产品介绍 Polyclonal antibody raised in rabbit against human JMJD2b (Jumonji Domain containing 2b), using a KLH-conjugated synthetic peptide containing an amino acid sequence from the central part of the protein.
询价
