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背景介绍 TATA-binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found approximately 30 base pairs upstream of the transcription start site in 10-20% of eukaryotic gene promoters. TBP is a subunit of the eukaryotic transcription factor TFIID. TBP is also a component of RNA polymerase I and RNA polymerase III, and is thought to be the only common subunit required by all three RNA polymerases. 产品介绍 Monoclonal antibody raised in mouse against the amino-terminal domain of human TBP (TATA box binding protein).
询价背景介绍 SirT1 (UniProtKB/Swiss-Prot entry Q96EB6) is a NAD-dependent deacetylase, which regulates processes such as apoptosis and muscle differentiation by the deacetylation of key regulatory proteins. Deacetylation of lysine 382 of p53/TP53 by Sirt1 impairs its ability to induce the proapoptotic program and modulate cell senescence, whereas deacetylation of TAF1B represses rDNA transcription by the RNA polymerase I. SirT1 is also involved in HES1- and HEY2-mediated transcriptional repression and inhibits skeletal muscle differentiation by deacetylating PCAF and MYOD1. SirT1 is recruited to the nuclear bodies via its interaction with PML 产品介绍 Monoclonal antibody raised in mouse against human SIRT1 (NAD-dependent deacetylase sirtuin-1) using a synthetic peptide
询价背景介绍 SETD8 (UniProtKB/Swiss-Prot entry Q9NQR1) is a histone methyl transferase that specifically monomethylates Lys-20 of histone H4. This histone modification represents a specific tag for epigenetic transcriptional repression en is enriched during mitosis. SETD8 may also play a role in maintaining silent chromatin by preventing the acetylation of the H4 tail. 产品介绍 Polyclonal antibody raised in rabbit against human SETD8 (SET domain containing 8), using the full length protein containing a Flag-tagged N-terminus and a His-tagged C terminus.
询价背景介绍 SETD1B (UniProt/Swiss-Prot entry Q9UPS6) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1B shows a non-overlapping localization with SETD1A, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression. 产品介绍 Polyclonal antibody raised in rabbit against mouse Setd1b (Set domain containing 1B), using a 3 KLH-conjugated synthetic peptides containing sequences from the central part of the protein
询价背景介绍 SETD1A (UniProt/Swiss-Prot entry O15047) is a component of the SET1 histone methyltransferase (HMT) complex. This complex specifically methylates lysine 4 of histone H3, but only if the neighboring lysine 9 residue is not yet methylated. Methylation of H3K4 represents a specific tag for epigenetic transcriptional activation. SETD1A shows a non-overlapping localization with SETD1B, suggesting that both proteins play a specific role in the epigenetic control of chromatin structure and gene expression. 产品介绍 Polyclonal antibody raised in rabbit against mouse Setd1a (Set domain containing 1A), using three KLH-conjugated synthetic peptides: two containing an amino acid sequence from the N-terminal part of the protein and one containing an amino acid sequence from the central part of the protein
询价背景介绍 Set9 (UniProtKB/Swiss-Prot entry Q8WTS6) is a histone methyltransferase which specifically methylates lysine 4 of histone H3 being a specific tag for epigenetic transcriptional activation. Further, methylation of histone H3K4 by Set9 precludes deacetylation of H3 by the NuRD complex and impairs Suv39h1-mediated methylation of H3K9. Set9 also methylates the tumor suppressor p53 at lysine 372, thereby enhancing its stability. It contains a SET domain but lacks the pre- and post-SET domains. 产品介绍 Polyclonal antibody raised in rabbit against human Set9 (SET domain containing (lysine methyltransferase) 9), using a recombinant protein.
询价背景介绍 RbAp48 (UniProtKB/Swiss-Prot entry Q09028) is a component of several complexes which regulate chromatin metabolism. These include (1) the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; (2) the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; (3) the nucleosome remodelling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; (4) the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and (5) the NURF (nucleosome remodeling factor) complex. Therefore it may target chromatin assembly factors as well as chromatin remodeling factors and histone deacetylases to their histone substrates in a nucleosomal DNA dependent manner. 产品介绍 Monoclonal antibody raised in mouse against the full length human RbAp48 protein (Retinoblastoma-binding protein p48) fused to GST. The antibody recognizes both RbAp48 and RbAp46.
询价背景介绍 RARA (UniProtKB/Swiss-Prot entry P10276) is a receptor for retinoic acid, a vitamin A metabolite, which directly regulates gene expression in target cells by binding to specific DNA response elements. In the absence of its ligand, this receptor represses transcription through the recruitment of specific corepressors and of HDAC's, whereas binding of retinioc acid causes the recruitment of coactivators and HAT's. Translocations involving the RARA gene, often leading to a RARA/PML fusion protein, are a major cause of acute promyelocytic leukemia. 产品介绍 Polyclonal antibody raised in rabbit against human RARA (Retinoic Acid Receptor alpha) using two KLH-conjugated synthetic peptides containing sequences from the C-terminal region of the protein
询价背景介绍 RNA polymerase II (pol II) is a key enzyme in the regulation and control of gene transcription. It is able to unwind the DNA double helix, synthesize RNA, and proofread the result. Pol II is a complex enzyme, consisting of 12 subunits, of which the B1 subunit (UniProt/Swiss-Prot entry P24928) is the largest. Together with the second largest subunit, B1 forms the catalytic core of the RNA polymerase II transcription machinery. 产品介绍 Monoclonal antibody raised in mouse against the B1 subunit of RNA polymerase II (polymerase (RNA) II (DNA directed) polypeptide A) of wheat germ. Interacts with the highly conserved C-terminal domain of the protein containing the YSPTSPS repeat.
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