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背景介绍 CAMK2α is a ser/thr protein kinase that is a member of the Ca2+/calmodulin-dependent protein kinase family. CAMK2α is abundant in the brain as a major constituent of the postsynaptic density and is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its Ca2+/calmodulin-dependent activity, CAMK2α can undergo autophosphorylation, resulting in Ca2+/calmodulin-independent activity. The protein level of CAMK2α fluctuates during neuronal activity in cultured rat pup hippocampal neurons. The levels of CAMK2α increased with heightened neuronal activity (2). 产品介绍 Recombinant human calcium/calmodulin-dependent protein kinase II alpha (CaMK2α), GenBank Accession #NM_171825, full length, with an N-terminal GST-tag, MW = 74 kDa, expressed in Sf9 cells via a baculovirus expression system.
询价背景介绍 CAMK1δ or Ca2+/calmodulin-dependent kinase I-like kinase (CKLiK) is activated by Ca(2+) and calmodulin and is detected in CD34+-derived neutrophils and eosinophils, as well as in mature peripheral blood granulocytes (1). CAMK1δ exhibits Ca(2+)/CaM-dependent activity that is enhanced in vitro by phosphorylation of its Thr180 by CaM-K kinase (CaM-KK)alpha, consistent with detection of CAMK1D-activating activity in HeLa cells (2). 产品介绍 Recombinant human CAMK1δ, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CAMKIγ (CLICK-III), a member of CAMK family, is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. Full activation of CaMKIγ requires both Ca(2+)/CaM and phosphorylation by CAMKK. CAMKIγ transcripts is most abundant in neurons, with the highest levels in limited nuclei such as the central nucleus of the amygdala (CeA) and the ventromedial hypothalamus (1). 产品介绍 Recombinant human CAMK1γ (a.a. 1-330), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CAMKIγ (CLICK-III), a member of CAMK family, is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase. Full activation of CaMKIγ requires both Ca(2+)/CaM and phosphorylation by CAMKK. CAMKIγ transcripts is most abundant in neurons, with the highest levels in limited nuclei such as the central nucleus of the amygdala (CeA) and the ventromedial hypothalamus (1). 产品介绍 Recombinant human CAMK1γ, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CAMKIβ is thought to be involved in a variety of developmental processes including development of the central nervous system (1). CAMKIβ2, an isoform of mCAMKIβ, is mainly present in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS, the expression of CAMKIβ2 is detected in the mantle zone suggesting its possible involvement in the differentiation of neurons (2). 产品介绍 Recombinant mouse CAMK1β, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CAMK1 is a serine/threonine protein kinase that is a member of the multifunctional calcium/calmodulin-dependent protein kinase family. CAMK1 is ubiquitously expressed and phosphorylates a number of proteins including SYN1, SYN2, CREB and CFTR. In addition, Numb family of proteins may also be intracellular targets for CAMK1, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein (1). CAMK1 also plays an important role in the trafficking of HDAC7 between the cytoplasm and the nucleus. CAMK1 phosphorylates HDAC7 on multiple sites that lead to alteration in localization of HDAC7 (2). 产品介绍 Recombinant mouse CAMK1, full length, with N-terminal GST-tag, expressed in E. coli cells
询价产品介绍 Recombinant human CAMK4, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 ASK1, also known as MAPKKK5, activates MKK3, MKK4 (SEK1), and MKK6. Overexpression of ASK1 induces apoptotic cell death, and ASK1 is activated in cells treated with tumor necrosis factor-alpha (1). ASK1 interacts with members of the TRAF family and is activated by TRAF2 in the TNF-signaling pathway. After activation by TRAF2, ASK1 activates MKK4, which in turn activates JNK. Thus, ASK1 is a mediator of TRAF2-induced JNK activation (2). 产品介绍 Recombinant human ASK1 (649-946) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is NM_005923.
询价背景介绍 AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis (1). AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) (2) and via signaling pathways in response to adiponectin, leptin and CAMKKβ. 产品介绍 Recombinant human AMPK (combination of A2/B2/G2 subunits), full length, with C-terminal His-tags, expressed in Sf9 insect cells via a baculovirus expression system. MW = 69 kDa (A2), 36 kDa (B2), 65 kDa (G2).
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