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背景介绍 PRKG2 is a member of the cGMP-dependent protein kinase family and is highly expressed in brain, lung, and intestinal mucosa. PRKG2 mediates intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin (1). Mice deficient in PRKG2 are resistant to E. coli STa and developed dwarfism which is caused by a severe defect in endochondral ossification at the growth plates. PRKG2 phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. PRKG2 is a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function (2). 产品介绍 Recombinant human PRKG2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKN2 (also known as PRK2) is a Rho effector and a member of the protein kinase C superfamily of serine/threonine kinases. PKN2 is an essential regulator of both entry into mitosis and exit from cytokinesis in HeLa S3 cells (1). PKN2 is required for abscission of the midbody at the end of the cell division cycle and for phosphorylation and activation of Cdc25B, the phosphatase required for activation of mitotic cyclin/Cdk1 complexes at the G2/M transition. C-terminus of PKN2 could be a potential drug target for effector-specific pharmacological intervention of Rho-medicated biological processes (2). 产品介绍 Recombinant human PKN2, also known as PRK2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKD2 is a novel phorbol ester- and growth factor-stimulated serine/threonine kinase that contains two cysteine-rich motifs at the N terminus, a pleckstrin homology domain, and a catalytic domain (1). It exhibits the strongest homology to the serine/threonine protein kinases PKD/PKCµ and PKCν. The PKD family of enzymes have been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation (2). 产品介绍 Recombinant human PKD2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKCν , also known as PKD3, is a members of the protein kinase C (PKC) family of serine/threonine kinases that play critical roles in the regulation of cellular differentiation and proliferation in many cell types. PKCν is composed of 890 amino acid residues and the protein has 77.3% similarity to human PKCµ (PKCmu) and 77. 4% similarity to mouse PKD (1). The PKCν mRNA is ubiquitously expressed in various tissues and the gene is located between markers WI-9798 and D2S177 on chromosome 2p21 region. 产品介绍 Recombinant human PKCν (PKCnu), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 Protein kinase Cmu (PKCµ) is a member of the protein kinase C (PKC) family that differs from the other PKC isoenzymes in structural and enzymatic properties. PKCµ is a ubiquitous in nature with the highest expression in the thymus, lung and peripheral blood mononuclear cells (1). PKCµ forms a complex in vivo with a phosphatidylinositol 4-kinase and a phosphatidylinositol-4-phosphate 5-kinase. A region of PKCµ between the amino-terminal transmembrane domain and the pleckstrin homology domain is shown to be involved in the association with the lipid kinases (2). 产品介绍 Recombinant human PKCµ (PKCmu), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 Protein Kinase C theta (PKCθ) is important component in the intracellular signaling cascade (1). Recent studies have suggested that local accumulation of fat metabolites inside skeletal muscle may activate a serine kinase cascade involving PKCθ leading to defects in insulin signaling and glucose transport in skeletal muscle (2). Insulin resistance plays a primary role in the development of type 2 diabetes and may be related to alterations in fat metabolism. PKCθ is a crucial component mediating fat-induced insulin resistance in skeletal muscle and is a potential therapeutic target for the treatment of type 2 diabetes (2). 产品介绍 Recombinant human PKCθ (PKCtheta), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKCη is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCη is predominantly expressed in squamous cell epithelia and induces terminal differentiation of keratinocytes. PKCη that is endogenously expressed or overexpressed is found to associate with the cyclin E/cdk2/p21 complex in keratinocytes of mice and humans (1). 产品介绍 Recombinant human PKCη (PKCeta), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKCζ is an atypical isoform of the PKC family. PKCζ is found in both particulate and soluble fractions and cannot be activated by phorbol ester. Overexpression of PKCζ and subsequent phorbol ester treatment abolished phorbol ester-induced reduction in cell proliferation (1). Overexpression of PKCζ also potentiates phorbol ester-induced mitogen-activated protein (MAP) kinase activation in a PKC-dependent manner. PKCζ is an upstream modulator of p70S6K, an important regulator of cell proliferation (2). 产品介绍 Recombinant human PKCζ (PKCzeta), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PKCε is a member of the protein kinase C (PKC) family of serine- and threonine-specific protein kinases that can phosphorylate a wide variety of protein targets known to be involved in diverse cellular signaling pathways. PKCε is involved in many different cellular functions, such as neuron channel activation , cardioprotection from ischemia (1), heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may control anxiety-like behavior (2). 产品介绍 Recombinant human PKCε (PKCepsilon), full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
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