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背景介绍 RSK4 is a member of the 90- kDa ribosomal S6 kinase family which are important components of growth factor mediated stimulation of cellular proliferation, survival and differentiation. RSK4 is activated via coordinated phosphorylation by ERK and 3-phosphoinositide-dependent protein kinase-1 (PDK1) (1). RSK4 is often associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX) and choroideremia (CHM). RSK4 is most abundantly expressed in the brain and kidney (2). 产品介绍 Recombinant human RSK4 (ribosomal S6 kinase 4), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 RSK3 is a member of the RSK (ribosomal S6 kinase) family that encodes a 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal (1). RSK3 mRNA is widely expressed and is activated by growth factors, serum and phorbol ester. Upon stimulation, RSK3 translocates to the cell nucleus and phosphorylates nuclear proteins. RSK3 can bind to ERK1/2 and this association increases the duration of RSK3 activation (2). 产品介绍 Recombinant human RSK3 (ribosomal S6 kinase 3), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2). 产品介绍 Recombinant human RSK2 (ribosomal S6 kinase 2), full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 HIPK1 or homeodomain-interacting protein kinase 1 is a ser/thr protein kinase and a member of the HIPK family. HIPK 1 is a nuclear kinase that phosphorylates homeodomain transcription factors. HIPK1 phosphorylates DAXX and this leads to its relocalization and subsequent decrease in transcriptional repression activity (1). HIPK1also interacts with p53 and phosphorylates it on serine residues. HIPK 1 expression is elevated in breast cancer cell lines and embryonic fibroblasts from HIPK 1-null mice show more susceptibility to apoptosis induced by DNA damage (2). 产品介绍 Human HIPK1 (homeodomain-interacting protein kinase 1), also known as Myak and Nbak2 (GenBank Accession No. NM_152696), a.a. 156-555 with N-terminal GST tag, MW = 71 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 Aurora C is a member of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. Aurora C has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumors (1). Aurora C overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. Aurora C is an important regulator of both genomic integrity and cell cycle progression in cancer cells and is an attractive target for anticancer drug development (2). 产品介绍 Recombinant human Aurora C, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 AURORA A belongs to a multigenic family of mitotic serine/threonine kinases which are involved in the control of chromosome segregation. AURORA A is involved in centrosome separation, duplication and maturation as well as in bipolar spindle assembly and stability (1). AURORA A is expressed and active at the highest level during G2-M phase of the cell cycle. Overexpression of AURORA A has been found to be correlated with the grade of various human solid tumours. Ectopic AURORA A overexpression in any culture cell line leads to polyploidy and centrosome amplification (2). 产品介绍 Recombinant mouse AURORA A, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 PRKG1 is a homodimer, with each monomer containing a regulatory cGMP-binding domain and a catalytic domain (1). By Northern blot analysis PRKG1 was shown to be expressed at highest levels in bladder, uterus, adrenal gland, and fallopian tube. PRKG1 plays an important stimulatory role in platelet activation (2). Expression of recombinant PRKG1 in a reconstituted cell model enhanced von Willebrand factor-induced activation of the platelet integrin alpha-IIb/beta-3. Prkg1 knockout mice showed impaired platelet responses to VWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by VWF or low-dose thrombin was inhibited by PRKG1 inhibitors but enhanced by cGMP. 产品介绍 Recombinant human PRKG1, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 RSK1 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK1 contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. RSK1 encodes a predicted 735-amino acid protein containing 2 distinct consensus ATP-binding site sequences. RSK1 transcript is present in lymphocytes, skeletal muscle, liver, and adipose tissue (1). RSKs are implicated in the activation of the mitogen-activated kinase (MAPK) cascade and the stimulation of cell proliferation and differentiation (2). 产品介绍 Recombinant human RSK1 (ribosomal S6 kinase 1), also known as MAPKAPK1A, S6K-β1, and RPS6KA1 Genbank Accession #NM_002953, full length, with an N-terminal GST-tag, MW = 108 kDa, expressed in Sf9 cells via a baculovirus expression system.
询价背景介绍 PRKX is a serine/threonine protein kinase that is closely related to the catalytic subunit of the cAMP-dependent protein kinase. PRKX regulates epithelial morphogenesis during mammalian kidney development and PRKX expression markedly activates migration of cultured renal epithelial cells in the presence of cAMP. Aberrant adult kidney expression of PRKX is found in autosomal dominant polycystic kidney disease (1). PRKX is involved in macrophage and granulocyte maturation. Abnormal recombination between PRKX and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females (2). 产品介绍 Recombinant human PRKX, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
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