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产品介绍 ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.
询价产品介绍 Ruxolitinib, also known as INCB18424, is a potent and selective Janus kinase JAK1 and JAK2 inhibitor, with IC50s of 5.9 nM and 5.7 nM, respectively. It inhibited IL-6 and IL-23 effects at concentrations less than 50 nM. Ruxolitinib was effective in the rat adjuvant arthritis model and multiple murine models of arthritis.
询价产品介绍 Ruxolitinib, also known as INCB18424, is a potent and selective Janus kinase JAK1 and JAK2 inhibitor, with IC50s of 5.9 nM and 5.7 nM, respectively. It inhibited IL-6 and IL-23 effects at concentrations less than 50 nM. Ruxolitinib was effective in the rat adjuvant arthritis model and multiple murine models of arthritis.
询价背景介绍 BCKDK (Branched chain ketoacid dehydrogenase kinase) is a mitochondrial kinase found at high levels in skeletal muscle. BCKDK phosphorylates and inactivates BCKD, leading to an increase in branched amino acids. Abnormal activity of this enzyme leads to diseases such as maple syrup urine disease and cachexia. 产品介绍 Recombinant human BCKDK (Branched chain ketoacid dehydrogenase kinase), from amino acid 30 to end. In this construct the N-terminal end of the protein is fused to GST. The protein was affinity purified.
询价背景介绍 BCKDK (Branched chain ketoacid dehydrogenase kinase) is a mitochondrial kinase found at high levels in skeletal muscle. BCKDK phosphorylates and inactivates BCKD, leading to an increase in branched amino acids. Abnormal activity of this enzyme leads to diseases such as maple syrup urine disease and cachexia. 产品介绍 Recombinant human BCKDK (Branched chain ketoacid dehydrogenase kinase), from amino acid 30 to end. In this construct the N-terminal end of the protein is fused to GST. The protein was affinity purified.
询价产品介绍 SARS-CoV-2 Spike protein S1 subunit, receptor binding domain (Spike S1 RBD), GenBank Accession No. MN908947, a.a. 319-541, fused with HSA to SARS-CoV-2 Nucleocapsid protein (N-protein), GenBank Accession No. QHD43423, a.a 237-419, with C-terminal His-tag, Expressed in CHO cells. MW=130 kDa.
询价产品介绍 SARS-CoV-2 Spike protein S1 subunit, receptor binding domain (Spike S1 RBD), GenBank Accession No. MN908947, a.a. 319-541, fused with HSA to SARS-CoV-2 Nucleocapsid protein (N-protein), GenBank Accession No. QHD43423, a.a 237-419, with C-terminal His-tag, Expressed in CHO cells. MW=130 kDa.
询价产品介绍 SARS-CoV-2 Spike protein S1 subunit, receptor binding domain (Spike S1 RBD), GenBank Accession No. MN908947, a.a. 319-541, fused with HSA to SARS-CoV-2 Nucleocapsid protein (N-protein), GenBank Accession No. QHD43423, a.a 237-419, with C-terminal His-tag, Expressed in CHO cells. MW=130 kDa.
询价产品介绍 SARS-CoV-2 Spike protein S2 subunit, also known as 2019-nCoV Spike S2, GenBank Accession No. MN908947, a.a. 686-1212, with C-terminal Fc-tag, expressed in a CHO cell expression system. MW=130 kDa.
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