Z-VEID-FMK

背景介绍 VEID is the specific recognition sequence for caspase-6/Mch2. Caspase 6 is only one of at least three effector caspases, the others being caspase 3 and 7, that are active during caspasedependent apoptosisLoss of DNA-binding activity and TNFα-induced apoptosis can be prevented by Z-VEID-FMK. The caspase-6-speci?c inhibitor Z-VEID-FMK signi?cantly prevented apoptosis of caspase-6-microinjected neurons, and was also able to abolish the cleavage of procaspase-8, although caspase-6 is activated downstream of caspase-8 in Fas-mediated apoptosis. 产品介绍 Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability. Can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Z-VDVAD-FMK

背景介绍 VDVAD has been shown to be a preferred cleavage site for caspase-2. Caspase 2 is a very versatile caspase with multiple functions. It is a member of the family of cysteine proteases called caspases that cleave proteins only at an amino acid following an aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen with a long pro-domain. Pro-caspase-2 contains two subunits, p19 and p12. Caspase 2 associates with several proteins involved in apoptosis via its CARD domain, including RAIDD, ARC, and DEFCAP. Together with RAIDD and PIDD/LRDD, caspase 2 has been shown to form the PIDDosome, which may serve as an activation platform for the protease, although it may also be activated in the absence of PIDD. Caspase 2 may also form a complex with the DNA-PKcs and PIDD/LRDD, which is involved in DNA repair after DNA damage. 产品介绍 Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Z-VDVAD-FMK

背景介绍 VDVAD has been shown to be a preferred cleavage site for caspase-2. Caspase 2 is a very versatile caspase with multiple functions. It is a member of the family of cysteine proteases called caspases that cleave proteins only at an amino acid following an aspartic acid residue. Within this family, caspase 2 is part of the Ich-1 subfamily. Caspase 2 has a similar amino acid sequence to initiator caspases, including caspase 1, caspase 4, caspase 5, and caspase 9. It is produced as a zymogen with a long pro-domain. Pro-caspase-2 contains two subunits, p19 and p12. Caspase 2 associates with several proteins involved in apoptosis via its CARD domain, including RAIDD, ARC, and DEFCAP. Together with RAIDD and PIDD/LRDD, caspase 2 has been shown to form the PIDDosome, which may serve as an activation platform for the protease, although it may also be activated in the absence of PIDD. Caspase 2 may also form a complex with the DNA-PKcs and PIDD/LRDD, which is involved in DNA repair after DNA damage. 产品介绍 Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Z-FA-FMK

Z-FA-FMK

Z-FA-FMK

Z-DQMD-FMK

背景介绍 Z-DQMD-FMK is a potent cell-permeable inhibitor of caspase-3. Researchers have shown that expression of a short peptide of 15 amino acids, including DQMD leads to abrogation of the apoptotic cascade, and treatment of cells, expressing the DQMD peptide with two apoptosis inducers, etoposide and sodium nitroprusside blocks cell death by apoptosis. Stable expression of the DQMD peptide leads to protection of cells, following induction of apoptosis and to the outgrowth and enrichment of resistant cell colonies. 产品介绍 Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Inhibits MG 132-induced small cell lung cancer cell death in vitro. Z-DQMD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Z-DQMD-FMK

背景介绍 Z-DQMD-FMK is a potent cell-permeable inhibitor of caspase-3. Researchers have shown that expression of a short peptide of 15 amino acids, including DQMD leads to abrogation of the apoptotic cascade, and treatment of cells, expressing the DQMD peptide with two apoptosis inducers, etoposide and sodium nitroprusside blocks cell death by apoptosis. Stable expression of the DQMD peptide leads to protection of cells, following induction of apoptosis and to the outgrowth and enrichment of resistant cell colonies. 产品介绍 Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Inhibits MG 132-induced small cell lung cancer cell death in vitro. Z-DQMD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.

Z-DQMD-FMK

背景介绍 Z-DQMD-FMK is a potent cell-permeable inhibitor of caspase-3. Researchers have shown that expression of a short peptide of 15 amino acids, including DQMD leads to abrogation of the apoptotic cascade, and treatment of cells, expressing the DQMD peptide with two apoptosis inducers, etoposide and sodium nitroprusside blocks cell death by apoptosis. Stable expression of the DQMD peptide leads to protection of cells, following induction of apoptosis and to the outgrowth and enrichment of resistant cell colonies. 产品介绍 Z-DQMD-FMK is a synthetic peptide that irreversibly inhibits the activity of Caspase-3. Inhibits MG 132-induced small cell lung cancer cell death in vitro. Z-DQMD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.