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产品介绍 Human Bromodomain containing 2, also known as BRD2, RING3 or RNF3, GenBank Accession No. NM_005104, a.a. 65 - 187 corresponding to bromodomain 1 with N-terminal GST-tag, MW = 41.4 kDa, expressed in an E. coli expression system.
询价产品介绍 Human Bromodomain containing 2, also known as BRD2 or RNF3, GenBank Accession No. NM_005104, a.a. 339 - 459 corresponding to bromdomain 2 with N-terminal His-tag, MW = 15.1 kDa, expressed in an E. coli expression system.
询价产品介绍 Human Bromodomain containing 1, also known as BRD1 and BRL, GenBank Accession No. NM_014577, a.a. 561 - 668 corresponding to single bromodomain with N-terminal GST-tag, MW = 40 kDa, expressed in an E. coli expression system.
询价产品介绍 Human Bromodomain containing 1, also known as BRD1 and BRL, GenBank Accession No. NM_014577, a.a. 561 - 668 corresponding to single bromodomain with N-terminal His-tag, MW = 13.7 kDa, expressed in an E. coli expression system
询价产品介绍 Protein complex of human protein phosphatase 2A catalytic subunit _x0001_ (PP2A), also known as TPD3, RP-C, PP2Ac, and PPP2CA (GenBank Accession NM_002715, a.a. 2-309 with C-terminal Histag) and human protein phosphatase 2A regulatory subunit (PP2AR) (GenBank Accession NM_014225, a.a. 2-589 with Nterminal GST-tag). Co-expressed in a baculovirus-infected Sf9 cell expression system. MW = 36 kDa (PP2A) and 92 kDa (PP2AR).
询价背景介绍 Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. 产品介绍 Pseudophosphatase PTP-IA2, also known as PTPRN and ICA-512, GenBank accession no. NM_002846, a.a. 693- 979, with an N-terminal GST-tag, MW=58.8 kDa, expressed in an E. coli expression system.
询价背景介绍 PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity. 产品介绍 PTPµ (mu) (protein tyrosine phosphatase mu, also known as RPTPµ), catalytic domain, (a.a. 896-1175), (GenBank Accession No. NM_001105244) with N-terminal GST tag, MW=56.2 kDa, expressed in an E. coli expression system.
询价背景介绍 Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Positive regulator of platelet activation and thrombosis. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation through KDR dephosphorylation. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration through dephosphorylation of PDGFR. Negative regulator of EGFR signaling pathway via EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. 产品介绍 Protein tyrosine phosphatase DEP1 (density-enhanced phosphatase-1), also known as PTPRJ, PTP-eta and CD148 (GenBank accession no. NM_U10886), a.a. 1024-1306 (catalytic domain) with N-terminal GST-tag, MW=58.9 kDa, expressed in an E. coli expression system.
询价背景介绍 PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. 产品介绍 Protein tyrosine phosphatase PTPRG, also known as PTPγ (gamma) (GenBank accession No. NM_002841), a.a. 801-1147 (catalytic domain) with N-terminal GST-tag, MW=65.6 kDa, expressed in an E. coli expression system.
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