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产品介绍 Human EGFR T790M L858R (GenBank Accession No. NM_005228), a.a. 668-1210 with substitutions of Threonine790 to Methionine and Leucine858 to Arginine and an N-terminal GST-tag, MW= 88 kDa, expressed in a baculovirus expression system.
询价产品介绍 The SMARCA2 TR-FRET Assay Kit is designed to measure the inhibition of SMARCA2 (BRM) binding to its substrate in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple; a sample containing terbium-labeled donor, dye-labeled acceptor, SMARCA2, substrate, and an inhibitor is incubated for 120 minutes. Then, the fluorescence intensity is measured using a fluorescence reader.
询价产品介绍 The SMARCA4 TR-FRET Assay Kit is designed to measure the inhibition of SMARCA4 binding to its substrate in a homogeneous 384 reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple; a sample containing terbium-labeled donor, dye-labeled acceptor, SMARCA4, substrate, and an inhibitor is incubated for 120 minutes. Then, the fluorescence intensity is measured using a fluorescence reader.
询价产品介绍 The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cellsurface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. T790M, L858R and C797S mutations in EGFR cause resistance to known EGFR inhibitors. The EGFR(T790M/C797S/L858R) Kinase Assay Kit is designed to identify mutant-selective EGFR kinase inhibitors and to measure EGFR (T790M/C797S/L858R) kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 Vascular endothelial growth factor receptor 2 (VEGFR2), also called Kinase insert Domain receptor (KDR), is a tyrosine kinase (TK) receptor for VEGFs that plays a central role in tumor angiogenesis; therefore the inhibition of VEGFR2 is a promising therapeutic strategy for inhibiting angiogenesis and tumor growth. The VEGFR2 Kinase Assay Kit is designed to measure VEGFR2 kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. EGFR(L858R) mutation is found in ~40% of EGFR-mutated lung tumors. The EGFR(L858R) Kinase Assay Kit is designed to measure EGFR (L858R) Kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价产品介绍 The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. EGFR(T790M) mutation is found as a second-site mutation in ~50% of EGFR-mutated lung tumors. The mutant was shown to be resistant to most tyrosine kinase inhibitor medicines including Erlotinib and Gefitinib. The EGFR(T790M) Kinase Assay Kit is designed to measure EGFR (T790M) Kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The EGFR (T790M) Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR(T790M) enzyme, EGFR substrate, ATP and kinase assay buffer for 100 enzyme reactions.
询价背景介绍 The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. EGFR(T790M/L858R) is an EGFR activating and drug resistance mutant that can be found in non-small-cell lung cancer cells. 产品介绍 The EGFR(T790M/L858) Kinase Assay Kit is designed to measure EGFR (T790M/L858R) Kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The EGFR (T790M/L858R) Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR(T790M/L858R) enzyme, EGFR substrate, ATP and kinase assay buffer for 100 enzyme reactions.
询价产品介绍 The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family. Overexpression and/or hyperactivation of EGFR kinase is associated with several human cancers such as lung, glioblastoma, and epithelian tumors of the neck and head, leading to the development of anticancer therapeutics targeting EGFR. The EGFR Kinase Assay Kit is designed to measure EGFR Kinase activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent. The EGFR Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant EGFR enzyme, EGFR substrate, ATP and kinase assay buffer for 100 enzyme reactions.
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