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产品介绍 Human SUV39H2, GenBank Accession No. NM_024670, a.a. 26-350, with N-terminal GST-tag, MW= 63 kDa, expressed in an E. coli expression system.
询价产品介绍 Human SUV39H1, GenBank Accession No. NM_003173, a.a. 82-412, with N-terminal GST-tag, MW= 64 kDa, expressed in an E. coli expression system.
询价背景介绍 EZH2 is the catalytic subunit of the PRC2/EED-EZH2 complex, which methylates Lys9 (H3K9me) and Lys27 (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate Lys27 of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes. EZH2 can also methylate non-histone proteins such as the transcription factor GATA4. 产品介绍 Mutant version of our regular EZH2 5-member complex (Cat. # 51004), but with an Ala-to-Thr mutation on a.a. 738 of the EZH2 protein. Complex of human EZH2 (GenBank Accession No. NM_004456), (a-a 2-end ; A738T*) with N-terminal His tag, MW= 86 kDa, human EED (NM_003797) (a-a 2-end) with N-terminal Flag tag, MW= 51 kDa, human SUZ12 (NM_015355) (a-a 2-end) with N-terminal His tag, MW = 87 kDa, Human AEBP2 (NM_153207) (a-a 2-end) with N-terminal His tag, MW= 53 kDa, and human RbAp48 (NM_005610) (a-a 2-end) with N-terminal His tag, MW = 48 kDa, co-expressed in baculovirus expression system.
询价产品介绍 Human SUV4-20H2 (GenBank Accession No. NM_032701), a.a. 2-280, with N-terminal GST-tag, MW= 58 kDa, expressed in an E. coli expression system.
询价产品介绍 Human SET and MYNDcontaining protein 4 (SMYD4), also known as KIAA1936, amino acids 2- 804(end), with N-terminal FLAG-tag GenBank Accession No. NM_052928, MW = 90 kDa. This protein is expressed in a Baculovirus infected Sf9 cell expression system.
询价产品介绍 The SetDB1 Chemiluminescent Assay Kit is designed to measure SetDB1 activity for screening and profiling applications. The key to the SetDB1 Direct Activity Assay Kit is a highly specific antibody that recognizes the methylated K9 residue of Histone H3. With this kit, only three simple steps are required for methyltransferase detection. First, S-adenosylmethionine is incubated with a sample containing assay buffer and methyltransferase enzyme. Next, primary antibody is added. Finally, the strips are treated with an HRP-labeled secondary antibody followed by addition of the HRP substrate to produce chemiluminescence that can then be measured using a chemiluminescence reader.
询价产品介绍 Human SetDB1 (variant 2), also known as Histone-lysine Nmethyltransferase SETDB1, SET domain bifurcated 1, KMT1E, ERG-associated protein with SET domain (ESET), GenBank Accession No. NM_012432, a.a. 510- 1290(end) expressed in a Baculovirus Sf9 cell expression system. MW = 114 kDa.
询价背景介绍 Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer 产品介绍 Human PRMT7 (protein arginine methyltransferase 7), GenBank Accession No. NM_019023, a.a. 2-692(end) with N-terminal FLAG-tag, MW=80 kDa, expressed in Sf9 cells using a Baculovirus expression system.
询价背景介绍 Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS. 产品介绍 Human PRMT8 (protein arginine methyltransferase 8), GenBank Accession No. NM_019854, a.a. 61-394(end) with N-terminal His-FLAG-tag, MW=40.8 kDa, expressed in Sf9 cells using a Baculovirus expression system.
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