服务平台拥有丰富的技术服务经验，一流的仪器设备，先进的检测手段和严格的质量控制体系，力求为全球药物研发机构提供优质高效的技术服务
产品介绍 SYK of the nonreceptor tyrosine kinases plays a role in autoimmune diseases like Epstein Barr virus and hematopoietic malignancies. The SYK Assay Kit is designed to measure SYK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
询价背景介绍 The TNF family ligand B-cell Activating Factor (BAFF, also known as BLyS, TALL-1 or CD257, encoded by the TNFSF13B gene) is a Type II membrane-bound protein, which can be released as a soluble ligand upon proteolytic processing. This cytokine is a ligand for the receptors Transmembrane Activator and CAML Interactor (TACI, TNFRSF13B), BAFF Receptor (BAFF-R, TNFRSF13C) and B-cell Maturation Antigen (BCMA, TNFRSF17). These interactions promote cell survival and they play a crucial role in B cell development. In particular, BCMA signaling is an important player in the later stages of B cell differentiation, including the survival of long-lived bone marrow plasma cells and likely for the survival of plasmablasts. 产品介绍 The BAFF:BCMA[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of BAFF:BCMA signaling.The key to this kit is the high sensitivity of detection of biotin-labeled BCMA by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, BAFF is coated on a 96-well plate. Next, BCMA is incubated with BAFF on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can be measured using a chemiluminescence reader.
询价产品介绍 Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cAMP signaling. Mouse PDE1B, also known as cAMP-inhibited phosphodiesterase, has been implicated in cardiovascular function and fertility. The Mouse PDE1B Assay Kit is designed for identification of inhibitors of Mouse PDE1B using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by Mouse PDE1B to the binding agent. Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearlypolarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light. The key to the Mouse PDE1B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for Mouse PDE1B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing Mouse PDE1B for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.
询价产品介绍 Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cAMP signaling. Rat PDE1B, also known as calmodulin-dependent phosphodiesterase, is a dual specificity phosphodiesterase has been implicated in allergy, asthma, hypertension, and schizophrenia. PDE1B plays an important role in T cell activation and survival, and that PDE1B-targeted therapy might prove beneficial in leukemias and inflammatory disorders. The Rat PDE1B Assay Kit is designed for identification of inhibitors of Rat PDE1B using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by Rat PDE1B to the binding agent. Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearlypolarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light. The key to the Rat PDE1B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for Rat PDE1B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing Rat PDE1B for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.
询价产品介绍 c-Mer (MERTK) is a member of the TAM receptor kinases and plays an important role in cell proliferation/survival, adhesion/migration, and regulation of inflammatory cytokine release. Along with other members of this family, Axl and TYRO3, c-Mer is part of an emerging class of innate immune checkpoints participating in antitumoral immunity. Thus, it has been suggested that c-Mer inhibition could be a promising immunotherapeutic approach in cancer treatment. The c-Mer Kinase Assay Kit is designed to measure c-Mer activity for screening and profiling applications using ADPGlo® as a detection reagent.
询价背景介绍 ALKBH5 (AlkB Homolog 5, RNA Demethylase) is an enzyme that removes N6-Methyladenosine (m^6A) from target mRNAs. ALKBH5 has been connected to various cancers, viral replication, and metabolic diseases while also being shown to remove the alkylation damage and restore adenine in DNA. 产品介绍 The ALKBH5 Chemiluminescent Assay Kit is designed to measure ALKBH5 activity for screening and profiling applications. The key to the ALKBH5 Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to ALKBH5 demethylase activity. With this kit, only three simple steps on a microtiter plate are required for detection of demethylase activity. First, ALKBH5 enzyme is incubated with the substrate. Next, primary antibody is added. Finally, the plate is treated with an HRP-labeled secondary antibody followed by the addition of the HRP substrate to produce chemiluminescence that can be measured using a chemiluminescence reader.
询价背景介绍 B7-2 (CD86) signaling through CTLA4 (CD152) has been shown to inhibit T- cell activation. This co-inhibitory pathway can be overactive in many tumors, enabling cancers to escape the host's immune system. CTLA4-blocking antibodies, including Ipilimumab (Yervoy) and Tremelimumab, have shown clinical efficacy in treating cancer. 产品介绍 The CTLA4:B7-2[Biotinylated] Inhibitor Screening Assay Kit is designed for screening and profiling inhibitors of CTLA4:B7-2-biotin interaction. The key to this kit is the high sensitivity of detection of CTLA4 by streptavidin-HRP. Only a few simple steps on a microtiter plate are required for the assay. First, CTLA4 is coated on a 96-well plate. Next, B7-2-biotin is incubated with CTLA4 on the plate. Finally, the plate is treated with streptavidin-HRP followed by addition of an HRP substrate to produce chemiluminescence, which can then be measured using a chemiluminescence reader.
询价产品介绍 Biotinylated histone H3 peptide substrate optimized for use in the PHF8 (KDM7B) Homogeneous Assay Kit (BPS #50515).
询价背景介绍 Phosphodiesterases (PDEs) play an important role in the dynamic regulation of cAMP and cGMP signaling. PDE7B is highly expressed in the pancreas and in other various tissues. Inhibition of PDE7B leads to induction of apoptosis. Phosphodiesterases catalyze the hydrolysis of the phosphodiester bond in dye-labeled cyclic monophosphates. Beads selectively bind the phosphate group in the nucleotide product. This increases the size of the nucleotide relative to unreacted cyclic monophosphate. In the polarization assay, dye molecules with absorption transition vectors parallel to the linearly-polarized excitation light are selectively excited. Dyes attached to the rapidly-rotating cyclic monophosphates will obtain random orientations and emit light with low polarization. Dyes attached to the slowly-rotating nucleotide-bead complexes will not have time to reorient and therefore will emit highly polarized light. 产品介绍 The Mouse PDE7B Assay Kit is designed for identification of inhibitors of Mouse PDE7B using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by Mouse PDE7B to the binding agent. The key to the Mouse PDE7B Assay Kit is the specific binding agent. Using this kit, only two simple steps on a microtiter plate are required for Mouse PDE7B reactions. First, the fluorescently labeled cAMP is incubated with a sample containing Mouse PDE7B for 1 hour. Second, a binding agent is added to the reaction mix to produce a change in fluorescent polarization that can then be measured using a fluorescence reader equipped for the measurement of fluorescence polarization.
询价
