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产品介绍 Human secreted Programmed Cell Death 1 Ligand 1 (PD-L1)-Fc fusion protein, also known as CD274 and B7 homolog 1 (B7-H1) with a T20Q mutation, GenBank Accession No. NM_014143, amino acids 19-239, fused at the Cterminus with the Fc portion of human IgG1, with C-terminal Avi-tag™ expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag™ technology. MW = 54 kDa.
询价产品介绍 Human secreted OX40, also known as CD134, Tumor Necrosis Factor Receptor Superfamily Member 4, and TNFRSF4, GenBank Accession No. NM_003327, a.a. 29-216 with C-terminal Avitag™ and Histag, expressed in a HEK293 cell expression system. This protein is enzymatically biotinlabeled using Avitag™ technology. MW = 23.6 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation. Biotinylation was confirmed to be >90%.
询价产品介绍 Human secreted OX40, also known as CD134, Tumor Necrosis Factor Receptor Superfamily Member 4, and TNFRSF4, GenBank Accession No. NM_003327, a.a. 29-216 with C-terminal Avitag™ and Histag, expressed in a HEK293 cell expression system. This protein is enzymatically biotinlabeled using Avitag™ technology. MW = 23.6 kDa (monomer). This protein runs at a higher MW by SDS-PAGE due to glycosylation. Biotinylation was confirmed to be >90%.
询价背景介绍 PCSK9 (PCSK9 Biotin-Labeled) is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. 产品介绍 Human proprotein convertase subtilisin/kexin type 9 (PCSK9 Biotin-Labeled), also known as FH3, HCHOLA3, and PC9, GenBank Accession No. NM_174936, a.a. 31-692(end), with C-terminal His and Avi tags, MW=73.8 kDa (calculated), expressed in an HEK293 cell expression system and enzymatically biotinylated using Av-itag™; technology.
询价背景介绍 PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. 产品介绍 Human proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as FH3, HCHOLA3, and PC9, GenBank Accession No. NM_174936, a.a. 31-692(end), with C-terminal His and Avi tags, MW=73.8 kDa (calculated), expressed in an HEK293 cell expression system and enzymatically biotinylated using Avitag™ technology.
询价背景介绍 PCSK9 is a crucial player in the regulation of plasma cholesterol homeostasis. It binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation. Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway. Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways. 产品介绍 Human proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as FH3, HCHOLA3, and PC9, GenBank Accession No. NM_174936, a.a. 31-692(end), with C-terminal His and Avi tags, MW=73.8 kDa (calculated), expressed in an HEK293 cell expression system and enzymatically biotinylated using Avitag™ technology.
询价产品介绍 Human KIR2DL3, also known as Killer cell immunoglobulin-like receptor 2DL3, KIR2DS5 and KIRCL23. GenBank Accession No. NM_015868. a.a. 22-245 fused at the C terminus to the Fc portion of human IgG1 followed by a C-termina Avi-tag™ and expressed in a HEK293 cell expression system. MW=53 kDa This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%. This protein runs at a higher MW due to glycosylation.
询价产品介绍 Human KIR2DL3, also known as Killer cell immunoglobulin-like receptor 2DL3, KIR2DS5 and KIRCL23. GenBank Accession No. NM_015868. a.a. 22-245 fused at the C terminus to the Fc portion of human IgG1 followed by a C-termina Avi-tag™ and expressed in a HEK293 cell expression system. MW=53 kDa This protein is enzymatically biotinylated using Avi-Tag™ technology. Biotinylation is confirmed to be ≥90%. This protein runs at a higher MW due to glycosylation.
询价产品介绍 Phycoerythrin-labeled anti-GITR recombinant human antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.
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