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产品介绍 Anti-GITR recombinant human antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.
询价产品介绍 Anti-GITR recombinant human antibody recognizing the GITRL binding region of human GITR. This antibody has not been tested for cross-reactivity with any other species.
询价产品介绍 Mouse LAG3, Fc fusion protein (Human), also known as Lymphocyte-Activation Gene 3 and CD223, with C-terminal Avi-Tag™. GenBank Accession No. NM_008479, a.a. 23-442 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag™ technology. MW = 74 kDa.
询价产品介绍 Mouse LAG3, Fc fusion protein (Human), also known as Lymphocyte-Activation Gene 3 and CD223, with C-terminal Avi-Tag™. GenBank Accession No. NM_008479, a.a. 23-442 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avi-tag™ technology. MW = 74 kDa.
询价产品介绍 The PARPtrap™ Assay Kit for PARP2 is designed to measure PARP2/DNA complex formation in a high throughput screening assay using fluorescence polarization (FP). Similarly, to PARP1, PARP2 recognizes and binds damaged DNA via its DNA-binding domain. Binding to DNA activates PARP2 and in the presence of NAD+ PARP2 ribosylates itself (auto-ribosylation), which leads to PARP2 dissociation from the DNA due to the accumulated negative charge of the ribosyl polymer. In the presence of some inhibitors, however, PARP remains bound to the DNA, a phenomenon termed trapping. Trapped PARP-DNA complexes have been shown to be highly cytotoxic to cancer cells, therefore such inhibitors may be desirable for cancer treatment. The key to the PARPtrap™ Assay Kit is the fluorescent-labeled oligonucleotide duplex. In the absence of ribosylation, PARP2 binds to the fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after auto-ribosylation PARP2 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP2 inhibitor results in trapping of PARP2 to the fluorescent oligonucleotide duplex, and increases the FP signal in a dose dependent manner. The PARPtrap™ Assay Kit is a fluorescence polarization homogeneous assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.
询价产品介绍 The PARPtrap™ Assay Kit for PARP2 is designed to measure PARP2/DNA complex formation in a high throughput screening assay using fluorescence polarization (FP). Similarly, to PARP1, PARP2 recognizes and binds damaged DNA via its DNA-binding domain. Binding to DNA activates PARP2 and in the presence of NAD+ PARP2 ribosylates itself (auto-ribosylation), which leads to PARP2 dissociation from the DNA due to the accumulated negative charge of the ribosyl polymer. In the presence of some inhibitors, however, PARP remains bound to the DNA, a phenomenon termed trapping. Trapped PARP-DNA complexes have been shown to be highly cytotoxic to cancer cells, therefore such inhibitors may be desirable for cancer treatment. The key to the PARPtrap™ Assay Kit is the fluorescent-labeled oligonucleotide duplex. In the absence of ribosylation, PARP2 binds to the fluorescent probe, forming a large complex and resulting in the emission of highly polarized light. However, after auto-ribosylation PARP2 dissociates from the oligonucleotide duplex, which then rotates freely, emitting less polarized light (Fig. 1). Addition of a PARP2 inhibitor results in trapping of PARP2 to the fluorescent oligonucleotide duplex, and increases the FP signal in a dose dependent manner. The PARPtrap™ Assay Kit is a fluorescence polarization homogeneous assay. The FP signal is measured using a fluorescent microplate reader capable of measuring fluorescence polarization.
询价背景介绍 Coronaviruses (CoVs) primarily cause multiple respiratory and intestinal infections in humans and animals. CoVs may enter into the cells with the help of proteases such as Severe Acute Respiratory Syndrome Coronavirus 3C-like protease (SARS-CoV-1 3CL Protease). The 3CL protease, also known as Main Protease (Mpro), plays a vital role in processing the polyproteins that are translated from the viral RNA 3CL Protease inhibitors that can block viral replication are promising potential drug candidates that could be used to treat patients suffering with the coronavirus infection. 产品介绍 The 3CL Protease Assay Kit is designed to measure 3CL Protease sactivity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价背景介绍 Coronaviruses (CoVs) primarily cause multiple respiratory and intestinal infections in humans and animals. CoVs may enter into the cells with the help of proteases such as Severe Acute Respiratory Syndrome Coronavirus 3C-like protease (SARS-CoV-1 3CL Protease). The 3CL protease, also known as Main Protease (Mpro), plays a vital role in processing the polyproteins that are translated from the viral RNA 3CL Protease inhibitors that can block viral replication are promising potential drug candidates that could be used to treat patients suffering with the coronavirus infection. 产品介绍 The 3CL Protease Assay Kit is designed to measure 3CL Protease sactivity for screening and profiling applications, in a homogeneous assay with no time-consuming washing steps.
询价产品介绍 The Papain-like Protease (PLPro) Assay Buffer is optimized for use with the Papain-like Protease (SARS-CoV-2): Protease Activity Assay Kit (BPS Bioscience #79995).
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