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背景介绍 EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes. EPZ004777 produces potent antitumor efficacy, and significantly increases median survival in a mouse xenograft model of MLL leukemia. Following DOT1L inhibition, EPZ004777 selectively inhibits proliferation of MLL-rearranged cell lines and MLL-AF9-transformed murine hematopoietic cells. In addition, EPZ004777 also induces differentiation and apoptosis in MLL-rearranged cells. DOT1L inhibition by EPZ004777 results in significantly decreased proliferation, decreased expression of MLL-AF6 target genes, and cell cycle arrest of MLL-AF6-transformed cells. EPZ004777 has also been found to selectively inhibit the proliferation of MLL-AF10 and CALM-AF10 transformed cells in a dose dependent manner (IC50: 0.1 µM to 1 µM), in which the mRNA expression levels of two hallmark leukemogenic genes (Hoxa9 and Meis1) are suppressed by EPZ004777 in a concentration dependent manner. 产品介绍 EPZ004777 is a potent, selective DOT1L inhibitor with IC50 of 400 pM. EPZ004777 selectively kills a variety of MLL-rearranged leukemia cells, including an MLL-AF4 leukemia cell line MV4-11 and an MLL-AF9 leukemia cell line MOLM13.
询价背景介绍 Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes. 产品介绍 Bromosporine is a broad spectrum inhibitor for bromodomains.
询价产品介绍 Biotinylation reagent with maleimide group. React specifically with reduced thiols (sulfhydryl groups), such as cysteine-containing peptides, at pH 6.5-7.5.
询价产品介绍 Biotinylation reagent with maleimide group. React specifically with reduced thiols (sulfhydryl groups), such as cysteine-containing peptides, at pH 6.5-7.5.
询价产品介绍 Biotinylation reagent with a pentafluorophenyl ester group. More reactive than the NHS ester group, targeting both primary and secondary amines. Suitable for biotin labeling of both proteins and amino acids.
询价产品介绍 Biotinylation reagent with a pentafluorophenyl ester group. More reactive than the NHS ester group, targeting both primary and secondary amines. Suitable for biotin labeling of both proteins and amino acids.
询价产品介绍 Biotinylation reagent with N-hydroxysuccinimide ester, and a 4 PEG spacer. The NHS group reacts with primary amines at pH 7.0-9.0. Can be used to label the e-amino group on lysines, the N-terminus of proteins, and other primary amines.
询价产品介绍 Biotinylation reagent with N-hydroxysuccinimide ester, and a 4 PEG spacer. The NHS group reacts with primary amines at pH 7.0-9.0. Can be used to label the e-amino group on lysines, the N-terminus of proteins, and other primary amines.
询价产品介绍 Biotinylation reagent with N-hydroxysuccinimide ester, and a 4 PEG spacer. The NHS group reacts with primary amines at pH 7.0-9.0. Can be used to label the e-amino group on lysines, the N-terminus of proteins, and other primary amines.
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