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背景介绍 HIPK3 (homeodomain interacting protein kinase 3) is a member of the HIPK family and is involved in apoptosis (1). JNK regulates the expression of HIPK3 in prostate cancer cells and this contributes to increased resistance to Fas receptor-mediated apoptosis by reducing the interaction between FADD and caspase-8 (2). HIPK3 has been reported to phosphorylate FADD and is implicated in multidrug resistance in a number of tumors. HIPK3 increases transcription factor SF-1 activity leading to increased steroidogenic gene expression in response to cAMP signaling. 产品介绍 Recombinant human HIPK3 (a.a. 163-562), with N-terminal His-tag, expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 HGK is the mitogen-activated protein kinase kinase kinase kinase 4(MAP4K4) and a member of the serine/threonine protein kinase family. HGK has been shown to specifically activate MAPK8/JNK (1). The activation of MAPK8 by HGK can be inhibited by dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggest that this kinase functions through the MAP3K7-MAP2K4-MAP2K7 kinase cascade and mediates TNF-α signaling. HGK-dependent signaling inhibits PPARγ-responsive gene expression, adipogenesis, and insulin-stimulated glucose transport (2). 产品介绍 Recombinant human HGK (a.a. 1-328), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 GRK7 is a member of the G protein-coupled receptor kinase subfamily and is a Ser/Thr protein kinase. GRK7 is specifically expressed in the retina and has been shown to phosphorylate cone opsins and initiate their deactivation (1). GRK7 catalyzes rhodopsin phosphorylation in a light-dependent manner. GRK7 co-localizes with GRK1 in human cone outer segments. PKA phosphorylates GRK7 at Ser(23) and Ser(36) in vitro and phosphorylation of GRK7 by PKA reduces the ability of GRK7 to phosphorylate rhodopsin in vitro (2). Since exposure to light causes a decrease in cAMP levels in rod cells, it is proposed that phosphorylation of GRK7 by PKA occurs in the dark. 产品介绍 Human GRK7, also known as GPRK7 (GenBank Accession No. NM_139209), full length, with N-terminal GST tag, MW ~89 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 GCK is a serine/threonine protein kinase that is activated by TNFα and interacts with the TNF receptor-associated factor 2 (TRAF2). GCK is upstream of MAP kinases and particularly activates the SAPK pathway (1). Although GCK is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. A mouse protein Rab8ip that has high homology to GCK can interact with the vesicular transport protein Rab8. Based on its interaction with Rab8, it is postulated that Rab8ip/GCK may modulate secretion in response to stress stimuli (2). 产品介绍 Human GCK, also known as MAP4K2, GenBank Accession No. NM_004579, full length, with N-terminal GST tag, MW ~125 kDa, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CDK9/CyclinK is a member of the cyclin-dependent protein kinase (CDK) family. CDK9 is closely related to cdc28 and cdc2 and is an important regulator of the cell cycle (1). CDK9 is a component of the multiprotein complex TAK/P-TEFβ. CDK9 can modulate RNA polymerase II-directed transcription by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. CDK9 forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. CDK9 also interacts with the HIV-1 Tat protein which suggested a possible involvement of this protein in AIDS (2). 产品介绍 Complex of recombinant human CDK9 and Cyclin K, full length, with N-terminal GST-tags, (GenBank Accession No. NM_001261, and BC015935, respectively) co-expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CDK2 is a member of the Cyclin-Dependent Kinase family that is ubiquitously expressed. CDK2 is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. CDK2 associates with and is regulated by the regulatory subunits of the complex including Cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B) (1). CDK2 phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition (2). 产品介绍 Complex of recombinant human CDK2 and CyclinE1, full length, with N-terminal GST-tags (GenBank Accession No. NM_001798, and NM_001238 respectively), co-expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes (1). Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated (2). 产品介绍 Complex of recombinant human CDK1 and CyclinA2, full length, with N-terminal GST-tags (GenBank Accession No. NM_001786, and NM_001237 respectively), co-expressed by Sf9 insect cells via a baculovirus expression system.
询价背景介绍 CDK6 is a member of the cyclin-dependent family of protein kinases that are important regulators of cell cycle progression. CDK6 activity is regulated by the D-type cyclins and members of the INK4 family of CDK inhibitors (1). The CDK6 kinase activity is detected in mid-G1 phase of the cell cycle and is responsible for the phosphorylation and regulation of the activity of tumor suppressor protein Rb. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein (2). 产品介绍 Complex of recombinant human CDK6, full length with N-terminal His-tag, and Cyclin D1, full length with N-terminal GST-tag (GenBank Accession Nos. NM_001259, and NM_053056 respectively) co-expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 Interleukin-1 receptor-associated kinase 2 (IRAK2) is important downstream signaling components of Toll-like receptors (TLRs) (1). IRAKs were first described as signal transducers for IL-1 and later have been implicated in signal transduction of other members of the Toll/IL-1 receptor family. The interleukin-1 receptor (IL-1R) signaling pathway leads to NF?B activation in mammals. To date, four mammalian IRAKs have been identified (IRAK-1, IRAK-2, IRAK-4, and IRAK-M) (2). It is believed that IRAK-2 could be an additional therapeutic target for inhibiting IL-1-induced inflammation. 产品介绍 Recombinant human IRAK2 (GenBank Accession No. NM_001570), full length with N-terminal GST tag, MW= 103 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
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