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背景介绍 AMPK (A1/B2/G1) is a member of the AMPK family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress (1). AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The β subunit may be a positive regulator of AMPK activity and is highly expressed in skeletal muscle (2). 产品介绍 Recombinant human AMPK (combination of A1/B2/G1 subunits), full length, with C-terminal His-tags, expressed in Sf9 insect cells via a baculovirus expression system. MW = 68 kDa (A1), 36 kDa (B2), 40 kDa (G1).
询价背景介绍 AMPK (A1/B1/G3) is a member of the AMPK family which are heterotrimeric proteins consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPKs are an important energy-sensing enzyme group in the cells that monitor energy status particularly in response to stress (1). AMPKs regulate fatty acid and cholesterol synthesis by regulating the key rate-limiting enzymes acetyl-CoA carboxylase and hydroxy beta-methylglutaryl-CoA reductase. The γ subunit is dominantly expressed in skeletal muscle where it may play a key role in the regulation of energy metabolism (2). 产品介绍 Recombinant human AMPK (combination of A1/B1/G3 subunits), full length, with C-terminal His-tags, expressed in Sf9 insect cells via a baculovirus expression system. MW = 68 kDa (A1), 38 kDa (B1), 51 kDa (G3).
询价背景介绍 AMP-activated protein kinase (AMPK) exhibits a key role as a master regulator of cellular energy homeostasis (1). AMPK exists as a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits. Binding of AMP to the γ subunit allosterically activates the complex. AMPK is activated in response to stresses that deplete cellular ATP (low glucose, hypoxia and ischemia) (2) and via signaling pathways in response to adiponectin, leptin and CAMKKβ. 产品介绍 Recombinant human AMPK (combination of A1/B1/G2 subunits), full length, with C-terminal His-tags, expressed by Sf9 insect cells via a baculovirus expression system. MW = 68 kDa (A1), 38 kDa (B1), 65 kDa (G2).
询价产品介绍 Complex of recombinant full-length human p110α (GenBank Accession No. NM_006218.2) with N345K mutation and N-terminal His-Tag, and recombinant full length, human p85α (GenBank Accession No. NM_181523), no tag. Co-expressed in Sf9 cells in a Baculovirus expression system. p110α (N345K) MW=111 kDa, p85α MW=86 kDa.
询价产品介绍 Complex of recombinant full-length human p110α (GenBank Accession No. NM_006218), with N-terminal His-Tag and recombinant full length, human p55γ (GenBank Accession No. NM_003629.2), no tag. Co-expressed in Sf9 cells in a Baculovirus expression system. p110α MW=111 kDa, p85α MW=61 kDa.
询价产品介绍 Complex of recombinant full-length human p110α (GenBank Accession No. NM_006218) with E545K mutation and N-terminal His-Tag, and recombinant full length, human p85α (GenBank Accession No. NM_181523), no tag. Co-expressed in Sf9 cells in a Baculovirus expression system. p110α (E545K) MW=111 kDa, p85α MW=86 kDa.
询价产品介绍 Human p53 protein, also known as cellular tumor antigen p53, tumor suppressor p53, and TP53, GenBank Accession No. NM_000546, a.a. 1-393(end), expressed in a baculovirus-infected Hi5 insect cell expression system. MW = 79 kDa.
询价背景介绍 TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity (1). Excessive TXK protein expression is seen in patients with Behcet's disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet's disease (2). 产品介绍 Recombinant human TXK (a.a. 239-end), with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
询价背景介绍 LYN is a 56 kd tyrosine kinase that is similar to mouse T-lymphocyte-specific tyrosine kinase p56lck, v-yes, v-fgr and v-src and is expressed in a variety of tissues (1). LYN is expressed preferentially in B cells and can be coimmunoprecipitated with IgM suggesting that LYN is physically associated with membrane-bound IgM, and participates in antigen-mediated signal transduction (2). Crosslinking of membrane-bound IgM with antibody induces rapid increase in activities of LYN and LYN-associated phosphatidylinositol 3-kinase. 产品介绍 Recombinant full-length human LYN B was expressed by baculovirus in Sf9 insect cells using an N-terminal GST-tag. The gene accession number is BC059394.
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