背景介绍 Receptor tyrosine-protein kinase erbB-2 (HER2 or CD340) is a protein that in humans is encoded by the ERBB2 gene. Over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. HER2 over-expression is also known to occur in ovarian, stomach, adenocarcinoma of the lung, aggressive forms of uterine cancer and gastric cancer. Signaling through the ErbB family of receptors promotes cell proliferation and opposes apoptosis, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. 产品介绍 Recombinant clonal stable CHO cell line constitutively expressing full length human ERBB2 protein (Genbank NM_004448.2). Surface expression of ERBB2 was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of ERBB2 expression (High, Medium, Low) to mimic different stages of cancer target cells with various ERBB2 expression levels.