背景介绍 PTPRF or LAR is a member of the protein tyrosine phosphatase family with an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. PTPRF has been shown to function in the regulation of epithelial cell-cell contacts at adherents junctions as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. 产品介绍 Human transmembrane leukocyte antigen related PTP (LAR), GenBank accession No. NM_130440, a.a. 1330-1620 (catalytic domain) with N-terminal GST-tag, MW=58 kDa, expressed in an E. coli expression system.